{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:46:43Z","timestamp":1764276403412},"reference-count":43,"publisher":"American Association for Cancer Research (AACR)","issue":"12","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC\/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C&amp;gt;A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus \u22123859G&amp;gt;A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2427\u201334)<\/jats:p>","DOI":"10.1158\/1055-9965.epi-06-0072","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T14:48:02Z","timestamp":1166021282000},"page":"2427-2434","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition"],"prefix":"10.1158","volume":"15","author":[{"given":"Antonio","family":"Agudo","sequence":"first","affiliation":[{"name":"1Unit of Epidemiology and"}]},{"given":"Nu\u0301ria","family":"Sala","sequence":"additional","affiliation":[{"name":"3Medical and Molecular Genetics Center, Institut d'Investigacio Biomedicale Bellvitge, Oncology Research Institute, Hospitalet de Llobregat, Barcelona, Spain;"}]},{"given":"Guillem","family":"Pera","sequence":"additional","affiliation":[{"name":"1Unit of Epidemiology and"}]},{"given":"Gabriel","family":"Capella\u0301","sequence":"additional","affiliation":[{"name":"2Laboratory of Translational Research, Institut d'Investigacio Biomedicale Bellvitge, Catalan Institute of Oncology and"}]},{"given":"Antonio","family":"Berenguer","sequence":"additional","affiliation":[{"name":"1Unit of Epidemiology and"}]},{"given":"Nadia","family":"Garci\u0301a","sequence":"additional","affiliation":[{"name":"2Laboratory of Translational Research, Institut d'Investigacio Biomedicale Bellvitge, Catalan Institute of Oncology and"},{"name":"3Medical and Molecular Genetics Center, Institut d'Investigacio Biomedicale Bellvitge, Oncology Research Institute, Hospitalet de Llobregat, Barcelona, Spain;"}]},{"given":"Domenico","family":"Palli","sequence":"additional","affiliation":[{"name":"4Epidemiology Unit, Center for Study and Prevention of Cancer, Florence, Italy;"}]},{"given":"Heiner","family":"Boeing","sequence":"additional","affiliation":[{"name":"5German Institute of Human Nutrition, Potsdam-Rehbru\u0308cke, Germany;"}]},{"given":"Giuseppe","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"6Immunobiological Research Institute of Siena, Chiron SPA, Siena, Italy;"}]},{"given":"Calogero","family":"Saieva","sequence":"additional","affiliation":[{"name":"4Epidemiology Unit, Center for Study and Prevention of Cancer, Florence, Italy;"}]},{"given":"Fatima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"7Institute of Molecular Pathology and Immunology, University of Porto and Medical Faculty, Porto, Portugal;"}]},{"given":"Franco","family":"Berrino","sequence":"additional","affiliation":[{"name":"8Department of Epidemiology, National Cancer Institute, Milan, Italy;"}]},{"given":"Carlotta","family":"Sacerdote","sequence":"additional","affiliation":[{"name":"9Unit of Cancer Epidemiology, University of Turin and Centro di Prevenzione Oncologica Piemonte, Turin, Italy;"}]},{"given":"Rosario","family":"Tumino","sequence":"additional","affiliation":[{"name":"10Cancer Registry, Azienda Ospedaliera Civile-M.P. Arezzo, Ragusa, Italy;"}]},{"given":"Salvatore","family":"Panico","sequence":"additional","affiliation":[{"name":"11Department of Clinical and Experimental Medicine, Federico II University, Medical School, Naples, Italy;"}]},{"given":"Go\u0308ran","family":"Berglund","sequence":"additional","affiliation":[{"name":"12Malmo\u0308 Diet and Cancer Study, Lund University, Malmo\u0308, Sweden;"}]},{"given":"Henrik","family":"Sima\u0301n","sequence":"additional","affiliation":[{"name":"12Malmo\u0308 Diet and Cancer Study, Lund University, Malmo\u0308, Sweden;"}]},{"given":"Roger","family":"Stenling","sequence":"additional","affiliation":[{"name":"13Department of Medical Biosciences, Pathology and"}]},{"given":"Go\u0308ran","family":"Hallmans","sequence":"additional","affiliation":[{"name":"14Department of Public Health and Clinical Medicine, Nutritional Research, University of Umea\u030a, Umea\u030a, Sweden;"}]},{"given":"Carmen","family":"Marti\u0301nez","sequence":"additional","affiliation":[{"name":"15Andalusian School of Public Health, Granada, Spain;"}]},{"given":"Roberto","family":"Bilbao","sequence":"additional","affiliation":[{"name":"16Fundacio\u0301n Vasca de Innovacio\u0301n e Investigacio\u0301n Sanitarias, Sondika, Bizkaia, Spain;"}]},{"given":"Aurelio","family":"Barricarte","sequence":"additional","affiliation":[{"name":"17Public Health Institute, Navarra, Spain;"}]},{"given":"Carmen","family":"Navarro","sequence":"additional","affiliation":[{"name":"18Consejeri\u0301a de Sanidad y Consumo, Murcia, Spain;"}]},{"given":"Jose\u0301 R.","family":"Quiro\u0301s","sequence":"additional","affiliation":[{"name":"19Direccio\u0301n General de Salud Pu\u0301blica, Consejeri\u0301a de Salud y Servicios Sanitarios, Asturias, Spain;"}]},{"given":"Naomi","family":"Allen","sequence":"additional","affiliation":[{"name":"20Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom;"}]},{"given":"Tim","family":"Key","sequence":"additional","affiliation":[{"name":"20Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom;"}]},{"given":"Sheila","family":"Bingham","sequence":"additional","affiliation":[{"name":"21Medical Research Council Dunn Human Nutrition Unit, Cambridge, United Kingdom;"}]},{"given":"Kay-Tee","family":"Khaw","sequence":"additional","affiliation":[{"name":"21Medical Research Council Dunn Human Nutrition Unit, Cambridge, United Kingdom;"}]},{"given":"Jakob","family":"Linseisen","sequence":"additional","affiliation":[{"name":"22Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany;"}]},{"given":"Gabriele","family":"Nagel","sequence":"additional","affiliation":[{"name":"22Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany;"}]},{"given":"Kim","family":"Overvad","sequence":"additional","affiliation":[{"name":"23Department of Clinical Epidemiology, Aalborg Hospital and Aarhus University Hospital and Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark;"}]},{"given":"Anne","family":"Tjonneland","sequence":"additional","affiliation":[{"name":"24Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;"}]},{"given":"Anja","family":"Olsen","sequence":"additional","affiliation":[{"name":"24Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;"}]},{"given":"H. Bas","family":"Bueno-de-Mesquita","sequence":"additional","affiliation":[{"name":"25Centre for Nutrition and Health, National Institute for Public Health and the Environment;"}]},{"given":"Hendriek C.","family":"Boshuizen","sequence":"additional","affiliation":[{"name":"26Centre for Information Technology and Methodology, National Institute for Public Health and the Environment, Bilthoven, the Netherlands;"}]},{"given":"Petra H.","family":"Peeters","sequence":"additional","affiliation":[{"name":"27Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands;"}]},{"given":"Mattijs E.","family":"Numans","sequence":"additional","affiliation":[{"name":"27Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands;"}]},{"given":"Franc\u0327oise","family":"Clavel-Chapelon","sequence":"additional","affiliation":[{"name":"28Institut National de la Sante et de la Recherche Medicale, Equipe E3N, Institut Gustave Roussy, Villejuif, France;"}]},{"given":"Marie-Christine","family":"Boutron-Ruault","sequence":"additional","affiliation":[{"name":"28Institut National de la Sante et de la Recherche Medicale, Equipe E3N, Institut Gustave Roussy, Villejuif, France;"}]},{"given":"Antonia","family":"Trichopoulou","sequence":"additional","affiliation":[{"name":"29Department of Hygiene and Epidemiology, Medical School, University of Athens, Athens, Greece;"}]},{"given":"Eiliv","family":"Lund","sequence":"additional","affiliation":[{"name":"30Institute of Community Medicine, University of Tromso, Tromso, Norway;"}]},{"given":"Johan","family":"Offerhaus","sequence":"additional","affiliation":[{"name":"31Pathology Department, Academic Medical Centre, Amsterdam, the Netherlands;"}]},{"given":"Mazda","family":"Jenab","sequence":"additional","affiliation":[{"name":"32Unit of Nutrition and Cancer, IARC, Lyon, France; and"}]},{"given":"Pietro","family":"Ferrari","sequence":"additional","affiliation":[{"name":"32Unit of Nutrition and Cancer, IARC, Lyon, France; and"}]},{"given":"Teresa","family":"Norat","sequence":"additional","affiliation":[{"name":"32Unit of Nutrition and Cancer, IARC, Lyon, France; and"}]},{"given":"Elio","family":"Riboli","sequence":"additional","affiliation":[{"name":"33Cancer Epidemiology and Prevention, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom"}]},{"given":"Carlos A.","family":"Gonza\u0301lez","sequence":"additional","affiliation":[{"name":"1Unit of Epidemiology and"}]}],"member":"1086","published-online":{"date-parts":[[2006,12,12]]},"reference":[{"key":"2022061002375698700_BIB1","unstructured":"International Agency for Research on Cancer. 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