{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:37:14Z","timestamp":1767915434016,"version":"3.49.0"},"reference-count":53,"publisher":"American Association for Cancer Research (AACR)","issue":"3","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polymorphisms within interleukin-1 (IL1) and tumor necrosis factor \u03b1 (TNFA) gene clusters are associated with an increased risk of gastric cancer. However, their role in gastric precancerous lesions remains poorly understood. Our objective was to perform a meta-analysis of studies addressing the association between IL1B-511, IL1RN variable number of tandem repeat, and TNFA-308 gene polymorphisms and gastric precancerous lesions, including original data from Portugal and Mozambique. Published studies on the association between these cytokine gene polymorphisms and gastric precancerous lesions were identified by systematic review, and estimates of the association were combined using random-effects meta-analysis taking into account new data obtained from Portuguese volunteer shipyard workers (n = 215) and Mozambican dyspeptic patients (n = 96) who underwent endoscopic and pathologic evaluation following the same protocol. Odds ratio (OR) estimates for intestinal metaplasia were 2.83 [95% confidence interval (95% CI), 1.15-6.96] for the IL1RN*22 genotype, 1.86 (95% CI, 1.03-3.36) for IL1B-511 T carriers, and 0.59 (95% CI, 0.12-3.04) for the TNFA-308*AA genotype in the Portuguese sample. All Mozambican subjects with intestinal metaplasia were T carriers for IL1B-511 and none had the 2 allele for IL1RN. In meta-analysis, IL1RN*22 genotype was associated with an increased risk of gastric precancerous lesions (22 versus LL: OR, 2.27; 95% CI, 1.40-3.70; I2 = 26.4%; 12 studies). No such association was found for the IL1B-511 (TT versus CC: OR, 1.34; 95% CI, 0.87-2.07; I2 = 65.7%; 13 studies) or TNFA-308 genotypes (AA versus GG: OR, 0.93; 95% CI, 0.35-2.43; I2 = 0.0%; 7 studies). The IL1RN*22 genotype seems to consistently increase the risk of gastric precancerous lesions, supporting a role for this polymorphism in the early stages of gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev; 19(3); 762\u201376<\/jats:p>","DOI":"10.1158\/1055-9965.epi-09-0917","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T14:17:58Z","timestamp":1268144278000},"page":"762-776","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Association Between Cytokine Gene Polymorphisms and Gastric Precancerous Lesions: Systematic Review and Meta-analysis"],"prefix":"10.1158","volume":"19","author":[{"given":"B\u00e1rbara","family":"Peleteiro","sequence":"first","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"},{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"}]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"},{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"}]},{"given":"Carla","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"},{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"}]},{"given":"Cec\u00edlia","family":"Dur\u00e3es","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"}]},{"given":"Jos\u00e9 Carlos","family":"Machado","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"},{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"},{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"}]},{"given":"Henrique","family":"Barros","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"},{"name":"Authors' Affiliations:\u20081Department of Hygiene and Epidemiology, and 2Department of Pathology, Medical Faculty, and 3Institute of Public Health and 4Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal; 5Department of Pathology, Medical Faculty, Eduardo Mondlane University and 6Department of Anatomical Pathology, Maputo Central Hospital, Maputo, Mozambique; and 7Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d and 8Istituto di Statistica Medica e Biometria, Universita di Milano, Milano, Italy"}]}],"member":"1086","published-online":{"date-parts":[[2010,3,9]]},"reference":[{"key":"2022060919495021900_bib1","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. 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