{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:44:58Z","timestamp":1775043898269,"version":"3.50.1"},"reference-count":8,"publisher":"American Association for Cancer Research (AACR)","issue":"1","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background:BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.<\/jats:p>\n                  <jats:p>Methods: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.<\/jats:p>\n                  <jats:p>Results: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.<\/jats:p>\n                  <jats:p>Conclusion: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and\/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.<\/jats:p>\n                  <jats:p>Impact: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1\/2 penetrance than candidate gene studies. Cancer Epidemiol Biomarkers Prev; 24(1); 308\u201316. \u00a92014 AACR.<\/jats:p>","DOI":"10.1158\/1055-9965.epi-14-0532","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T01:10:27Z","timestamp":1413940227000},"page":"308-316","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in\n                    <i>BRCA1<\/i>\n                    and\n                    <i>BRCA2<\/i>\n                    Mutation Carriers"],"prefix":"10.1158","volume":"24","author":[{"given":"Paolo","family":"Peterlongo","sequence":"first","affiliation":[{"name":"1IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy."},{"name":"2Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy."}]},{"given":"Jenny","family":"Chang-Claude","sequence":"additional","affiliation":[{"name":"3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"Kirsten B.","family":"Moysich","sequence":"additional","affiliation":[{"name":"4Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York."}]},{"given":"Anja","family":"Rudolph","sequence":"additional","affiliation":[{"name":"3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"Rita K.","family":"Schmutzler","sequence":"additional","affiliation":[{"name":"5Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany."},{"name":"6Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany."},{"name":"7Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany, on behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC)."}]},{"given":"Jacques","family":"Simard","sequence":"additional","affiliation":[{"name":"8Centre Hospitalier Universitaire de Qu\u00e9bec Research Center and Laval University, Quebec City, Canada."}]},{"given":"Penny","family":"Soucy","sequence":"additional","affiliation":[{"name":"8Centre Hospitalier Universitaire de Qu\u00e9bec Research Center and Laval University, Quebec City, Canada."}]},{"given":"Rosalind A.","family":"Eeles","sequence":"additional","affiliation":[{"name":"9Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, United Kingdom."}]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[{"name":"10Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom."}]},{"given":"Ute","family":"Hamann","sequence":"additional","affiliation":[{"name":"11Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"Stefan","family":"Wilkening","sequence":"additional","affiliation":[{"name":"12Genomic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"Bowang","family":"Chen","sequence":"additional","affiliation":[{"name":"13Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"Matti A.","family":"Rookus","sequence":"additional","affiliation":[{"name":"14Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands."}]},{"given":"Marjanka K.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"15Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands."}]},{"given":"Frederieke H.","family":"van der Baan","sequence":"additional","affiliation":[{"name":"14Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands."}]},{"given":"Amanda B.","family":"Spurdle","sequence":"additional","affiliation":[{"name":"16Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia."}]},{"given":"Logan C.","family":"Walker","sequence":"additional","affiliation":[{"name":"17Department of Pathology, University of Otago, Christchurch, New Zealand."}]},{"given":"Felicity","family":"Lose","sequence":"additional","affiliation":[{"name":"16Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia."}]},{"given":"Ana-Teresa","family":"Maia","sequence":"additional","affiliation":[{"name":"18Department of Biomedical Sciences and Medicine, Gambelas Campus, University of Algarve, Portugal."}]},{"given":"Marco","family":"Montagna","sequence":"additional","affiliation":[{"name":"19Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy."}]},{"given":"Laura","family":"Matricardi","sequence":"additional","affiliation":[{"name":"19Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy."}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[{"name":"20Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland."}]},{"given":"Anna","family":"Jakubowska","sequence":"additional","affiliation":[{"name":"20Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland."}]},{"given":"Encarna B.","family":"G\u00f3mez Garcia","sequence":"additional","affiliation":[{"name":"21Department of Clinical Genetics, MUMC, Maastricht, the Netherlands."}]},{"given":"Olufunmilayo I.","family":"Olopade","sequence":"additional","affiliation":[{"name":"22Center for Clinical Cancer Genetics, Department of Medicine and Human Genetics, University of Chicago Medical Center, Chicago, Illinois."}]},{"given":"Robert L.","family":"Nussbaum","sequence":"additional","affiliation":[{"name":"23Department of Medicine and Institute for Human Genetics, University of California, San Francisco, San Francisco, California."}]},{"given":"Katherine L.","family":"Nathanson","sequence":"additional","affiliation":[{"name":"24Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadephia, Pennsylvania."}]},{"given":"Susan M.","family":"Domchek","sequence":"additional","affiliation":[{"name":"24Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadephia, Pennsylvania."}]},{"given":"Timothy R.","family":"Rebbeck","sequence":"additional","affiliation":[{"name":"25Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadephia, Pennsylvania."}]},{"given":"Banu K.","family":"Arun","sequence":"additional","affiliation":[{"name":"26University of Texas MD Anderson Cancer Center, Houston, Texas."}]},{"given":"Beth Y.","family":"Karlan","sequence":"additional","affiliation":[{"name":"27Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California."}]},{"given":"Sandra","family":"Orsulic","sequence":"additional","affiliation":[{"name":"27Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California."}]},{"given":"Jenny","family":"Lester","sequence":"additional","affiliation":[{"name":"27Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California."}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[{"name":"28Departments of Pediatrics and Medicine, Columbia University, New York, New York."}]},{"given":"Alex","family":"Miron","sequence":"additional","affiliation":[{"name":"29Department of Genetics and Genomics at Case Western Reserve Medical School, Cleveland, Ohio."}]},{"given":"Melissa C.","family":"Southey","sequence":"additional","affiliation":[{"name":"30Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia."}]},{"given":"David E.","family":"Goldgar","sequence":"additional","affiliation":[{"name":"31Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah."}]},{"given":"Saundra S.","family":"Buys","sequence":"additional","affiliation":[{"name":"32Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah."}]},{"given":"Ramunas","family":"Janavicius","sequence":"additional","affiliation":[{"name":"33Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology, and Transfusion Medicine Center, Dept. of Molecular and Regenerative Medicine; State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania."}]},{"given":"Cecilia M.","family":"Dorfling","sequence":"additional","affiliation":[{"name":"34Department of Genetics, University of Pretoria, Pretoria, South Africa."}]},{"given":"Elizabeth J.","family":"van Rensburg","sequence":"additional","affiliation":[{"name":"34Department of Genetics, University of Pretoria, Pretoria, South Africa."}]},{"given":"Yuan Chun","family":"Ding","sequence":"additional","affiliation":[{"name":"35Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California."}]},{"given":"Susan L.","family":"Neuhausen","sequence":"additional","affiliation":[{"name":"35Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California."}]},{"given":"Thomas V.O.","family":"Hansen","sequence":"additional","affiliation":[{"name":"36Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark."}]},{"given":"Anne-Marie","family":"Gerdes","sequence":"additional","affiliation":[{"name":"37Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark."}]},{"given":"Bent","family":"Ejlertsen","sequence":"additional","affiliation":[{"name":"38Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark."}]},{"given":"Lars","family":"J\u00f8nson","sequence":"additional","affiliation":[{"name":"36Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark."}]},{"given":"Ana","family":"Osorio","sequence":"additional","affiliation":[{"name":"39Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain."},{"name":"40Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain."}]},{"given":"Cristina","family":"Mart\u00ednez-Bouzas","sequence":"additional","affiliation":[{"name":"41Molecular Genetics Laboratory, Department of Biochemistry, Cruces Hospital Barakaldo, 48903-Barakaldo-Bizkaia, Spain."}]},{"given":"Javier","family":"Benitez","sequence":"additional","affiliation":[{"name":"39Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain."},{"name":"42Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), Madrid, Spain."}]},{"given":"Edye E.","family":"Conway","sequence":"additional","affiliation":[{"name":"43Saint Alphonsus Regional Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California."}]},{"given":"Kathleen R.","family":"Blazer","sequence":"additional","affiliation":[{"name":"44Clinical Cancer Genetics, City of Hope, Duarte, California."}]},{"given":"Jeffrey N.","family":"Weitzel","sequence":"additional","affiliation":[{"name":"45Clinical Cancer Genetics, City of Hope, Duarte, California (for the City of Hope Clinical Cancer Genetics Community Research Network)."}]},{"given":"Siranoush","family":"Manoukian","sequence":"additional","affiliation":[{"name":"46Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy."}]},{"given":"Bernard","family":"Peissel","sequence":"additional","affiliation":[{"name":"46Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy."}]},{"given":"Daniela","family":"Zaffaroni","sequence":"additional","affiliation":[{"name":"46Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy."}]},{"given":"Giulietta","family":"Scuvera","sequence":"additional","affiliation":[{"name":"46Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy."}]},{"given":"Monica","family":"Barile","sequence":"additional","affiliation":[{"name":"47Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy."}]},{"given":"Filomena","family":"Ficarazzi","sequence":"additional","affiliation":[{"name":"1IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy."},{"name":"48Cogentech Cancer Genetic Test Laboratory, Milan, Italy."}]},{"given":"Frederique","family":"Mariette","sequence":"additional","affiliation":[{"name":"1IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy."},{"name":"48Cogentech Cancer Genetic Test Laboratory, Milan, Italy."}]},{"given":"Stefano","family":"Fortuzzi","sequence":"additional","affiliation":[{"name":"1IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy."},{"name":"48Cogentech Cancer Genetic Test Laboratory, Milan, Italy."}]},{"given":"Alessandra","family":"Viel","sequence":"additional","affiliation":[{"name":"49Division of Experimental Oncology 1, CRO Aviano National Cancer Institute, Aviano (PN), Italy."}]},{"given":"Giuseppe","family":"Giannini","sequence":"additional","affiliation":[{"name":"50Department of Molecular Medicine, Sapienza University, Rome, Italy."}]},{"given":"Laura","family":"Papi","sequence":"additional","affiliation":[{"name":"51Unit of Medical Genetics, Department of Biomedical, Experimental, and Clinical Sciences, University of Florence, Florence, Italy."}]},{"given":"Aline","family":"Martayan","sequence":"additional","affiliation":[{"name":"52Unit of Genetic Counseling, Medical Oncology Department, Istituto Nazionale Tumori Regina Elena, Rome, Italy."}]},{"given":"Maria Grazia","family":"Tibiletti","sequence":"additional","affiliation":[{"name":"53UO Anatomia Patologica Ospedale di Circolo e Fondazione Macchi, Polo Universitario Varese, Italy."}]},{"given":"Paolo","family":"Radice","sequence":"additional","affiliation":[{"name":"2Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy."}]},{"given":"Athanassios","family":"Vratimos","sequence":"additional","affiliation":[{"name":"54Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research \u201cDemokritos\u201d, Aghia Paraskevi Attikis, Athens, Greece."}]},{"given":"Florentia","family":"Fostira","sequence":"additional","affiliation":[{"name":"54Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research \u201cDemokritos\u201d, Aghia Paraskevi Attikis, Athens, Greece."}]},{"given":"Judy E.","family":"Garber","sequence":"additional","affiliation":[{"name":"55Dana-Farber Cancer Institute, Boston, Massachuestts."}]},{"given":"Alan","family":"Donaldson","sequence":"additional","affiliation":[{"name":"56Clinical Genetics Department, St. Michael's Hospital, Bristol, United Kingdom."}]},{"given":"Carole","family":"Brewer","sequence":"additional","affiliation":[{"name":"57Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom."}]},{"given":"Claire","family":"Foo","sequence":"additional","affiliation":[{"name":"58Cheshire & Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom."}]},{"given":"D. Gareth R.","family":"Evans","sequence":"additional","affiliation":[{"name":"59Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom."}]},{"given":"Debra","family":"Frost","sequence":"additional","affiliation":[{"name":"10Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom."}]},{"given":"Diana","family":"Eccles","sequence":"additional","affiliation":[{"name":"60University of Southampton, Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom."}]},{"given":"Angela","family":"Brady","sequence":"additional","affiliation":[{"name":"61North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, United Kingdom."}]},{"given":"Jackie","family":"Cook","sequence":"additional","affiliation":[{"name":"62Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom."}]},{"given":"Marc","family":"Tischkowitz","sequence":"additional","affiliation":[{"name":"63Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, United Kingdom."}]},{"given":"Julian","family":"Adlard","sequence":"additional","affiliation":[{"name":"64Yorkshire Regional Genetics Service, Leeds, United Kingdom."}]},{"given":"Julian","family":"Barwell","sequence":"additional","affiliation":[{"name":"65Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom."}]},{"given":"Lisa","family":"Walker","sequence":"additional","affiliation":[{"name":"66Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom."}]},{"given":"Louise","family":"Izatt","sequence":"additional","affiliation":[{"name":"67Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom."}]},{"given":"Lucy E.","family":"Side","sequence":"additional","affiliation":[{"name":"68North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom."}]},{"given":"M. John","family":"Kennedy","sequence":"additional","affiliation":[{"name":"69Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, Ireland."},{"name":"70St. James's Hospital, Dublin, Ireland."}]},{"given":"Mark T.","family":"Rogers","sequence":"additional","affiliation":[{"name":"71All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, United Kingdom."}]},{"given":"Mary E.","family":"Porteous","sequence":"additional","affiliation":[{"name":"72South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom."}]},{"given":"Patrick J.","family":"Morrison","sequence":"additional","affiliation":[{"name":"73Centre for Cancer Research and Cell Biology, Queens University of Belfast, Department of Medical Genetics, Belfast HSC Trust, Belfast, United Kingdom."}]},{"given":"Radka","family":"Platte","sequence":"additional","affiliation":[{"name":"10Centre for Cancer Genetic Epidemiology, Department of Public Health and 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K.","family":"Godwin","sequence":"additional","affiliation":[{"name":"77Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Missouri."}]},{"given":"Kathleen","family":"Claes","sequence":"additional","affiliation":[{"name":"78Center for Medical Genetics, Ghent University, Ghent, Belgium."}]},{"given":"Tom","family":"Van Maerken","sequence":"additional","affiliation":[{"name":"78Center for Medical Genetics, Ghent University, Ghent, Belgium."}]},{"given":"Alfons","family":"Meindl","sequence":"additional","affiliation":[{"name":"79Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany."}]},{"given":"Andrea","family":"Gehrig","sequence":"additional","affiliation":[{"name":"80Institute of Human Genetics, University W\u00fcrzburg, Wurzburg, Germany."}]},{"given":"Christian","family":"Sutter","sequence":"additional","affiliation":[{"name":"81University Heidelberg, 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Germany."}]},{"given":"Barbara","family":"Wappenschmidt","sequence":"additional","affiliation":[{"name":"5Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany."},{"name":"6Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany."},{"name":"87Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany."}]},{"given":"Shan","family":"Wang-Gohrke","sequence":"additional","affiliation":[{"name":"91Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany."}]},{"given":"Brigitte","family":"Bressac-de Paillerets","sequence":"additional","affiliation":[{"name":"92INSERM U946, Fondation Jean Dausset, Paris, France."},{"name":"93Service de G\u00e9n\u00e9tique, Institut de Canc\u00e9rologie Gustave Roussy, Villejuif, France."}]},{"given":"Bruno","family":"Buecher","sequence":"additional","affiliation":[{"name":"94Institut Curie, Department of Tumour Biology, Paris, France."}]},{"given":"Capucine","family":"Delnatte","sequence":"additional","affiliation":[{"name":"95Centre Ren\u00e9 Gauducheau, Nantes, France."}]},{"given":"Claude","family":"Houdayer","sequence":"additional","affiliation":[{"name":"94Institut Curie, Department of Tumour Biology, Paris, France."},{"name":"96Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, France."}]},{"given":"Dominique","family":"Stoppa-Lyonnet","sequence":"additional","affiliation":[{"name":"94Institut Curie, Department of Tumour Biology, Paris, France."},{"name":"96Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, France."},{"name":"97Institut Curie, INSERM U830, Paris, France."}]},{"given":"Francesca","family":"Damiola","sequence":"additional","affiliation":[{"name":"98INSERM U1052, CNRS UMR5286, Universit\u00e9 Lyon 1, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon, France."}]},{"given":"Isabelle","family":"Coupier","sequence":"additional","affiliation":[{"name":"99Unit\u00e9 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M.","family":"Sinilnikova","sequence":"additional","affiliation":[{"name":"98INSERM U1052, CNRS UMR5286, Universit\u00e9 Lyon 1, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon, France."},{"name":"102Unit\u00e9 Mixte de G\u00e9n\u00e9tique Constitutionnelle des Cancers Fr\u00e9quents, Hospices Civils de Lyon \u2013 Centre L\u00e9on B\u00e9rard, Lyon, France."},{"name":"1IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy."}]},{"given":"Olivier","family":"Caron","sequence":"additional","affiliation":[{"name":"103Consultation de G\u00e9n\u00e9tique, D\u00e9partement de M\u00e9decine, Institut de Canc\u00e9rologie Gustave Roussy, Villejuif, France."}]},{"given":"Pascal","family":"Pujol","sequence":"additional","affiliation":[{"name":"99Unit\u00e9 d'Oncog\u00e9n\u00e9tique, CHU Arnaud de Villeneuve, Montpellier, France."},{"name":"104INSERM 896, CRCM Val d'Aurelle, Montpellier, 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