{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:55:27Z","timestamp":1772164527175,"version":"3.50.1"},"reference-count":34,"publisher":"American Association for Cancer Research (AACR)","issue":"13","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpose: As genome-scale technologies begin to unravel the complexity of the equivalent tumors in adults, we can attempt detailed characterization of high-grade gliomas in children, that have until recently been lacking. Toward this end, we sought to validate and extend investigations of the differences between pediatric and adult tumors.<\/jats:p>\n                  <jats:p>Experimental Design: We carried out copy number profiling by array comparative genomic hybridization using a 32K bacterial artificial chromosome platform on 63 formalin-fixed paraffin-embedded cases of high-grade glioma arising in children and young people (&amp;lt;23 years).<\/jats:p>\n                  <jats:p>Results: The genomic profiles of these tumors could be subclassified into four categories: those with stable genomes, which were associated with a better prognosis; those with aneuploid and those with highly rearranged genomes; and those with an amplifier genotype, which had a significantly worse clinical outcome. Independent of this was a clear segregation of cases with 1q gain (more common in children) from those with concurrent 7 gain\/10q loss (a defining feature of adults). Detailed mapping of all the amplification and deletion events revealed numerous low-frequency amplifications, including IGF1R, PDGFRB, PIK3CA, CDK6, CCND1, and CCNE1, and novel homozygous deletions encompassing unknown genes, including those at 5q35, 10q25, and 22q13. Despite this, aberrations targeting the \u201ccore signaling pathways\u201d in adult glioblastomas are significantly underrepresented in the pediatric setting.<\/jats:p>\n                  <jats:p>Conclusions: These data highlight that although there are overlaps in the genomic events driving gliomagenesis of all ages, the pediatric disease harbors a distinct spectrum of copy number aberrations compared with adults. Clin Cancer Res; 16(13); 3368\u201377. \u00a92010 AACR.<\/jats:p>","DOI":"10.1158\/1078-0432.ccr-10-0438","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T00:07:24Z","timestamp":1277251644000},"page":"3368-3377","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas"],"prefix":"10.1158","volume":"16","author":[{"given":"Dorine A.","family":"Bax","sequence":"first","affiliation":[{"name":"Authors' Affiliations:\u20081Section of Paediatric Oncology, The Institute of Cancer Research, and 2Paediatric Oncology, Royal Marsden Hospital, Sutton, United Kingdom; 3Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, and 4Breakthrough Breast Cancer Unit and 5Clinical Neuropathology, Kings College Hospital, London, United Kingdom; 6Life and Health Sciences Research Institute, University do Minho, Braga, Portugal; 7Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; and 8St Jude Children's Research Hospital, Memphis, Tennessee"}]},{"given":"Alan","family":"Mackay","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Section of Paediatric Oncology, The Institute of Cancer Research, and 2Paediatric Oncology, Royal Marsden Hospital, Sutton, United Kingdom; 3Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, and 4Breakthrough Breast Cancer Unit and 5Clinical Neuropathology, Kings College Hospital, London, United Kingdom; 6Life and Health Sciences Research Institute, University do Minho, Braga, Portugal; 7Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; and 8St Jude Children's Research Hospital, Memphis, Tennessee"}]},{"given":"Suzanne E.","family":"Little","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Section of Paediatric 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Kingdom; 3Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, and 4Breakthrough Breast Cancer Unit and 5Clinical Neuropathology, Kings College Hospital, London, United Kingdom; 6Life and Health Sciences Research Institute, University do Minho, Braga, Portugal; 7Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; and 8St Jude Children's Research Hospital, Memphis, Tennessee"}]},{"given":"Marta","family":"Viana-Pereira","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Section of Paediatric Oncology, The Institute of Cancer Research, and 2Paediatric Oncology, Royal Marsden Hospital, Sutton, United Kingdom; 3Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, and 4Breakthrough Breast Cancer Unit and 5Clinical Neuropathology, Kings College Hospital, London, United Kingdom; 6Life and Health Sciences Research Institute, University do Minho, Braga, Portugal; 7Center for Neuroscience 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Breast Cancer Research Centre, The Institute of Cancer Research, and 4Breakthrough Breast Cancer Unit and 5Clinical Neuropathology, Kings College Hospital, London, United Kingdom; 6Life and Health Sciences Research Institute, University do Minho, Braga, Portugal; 7Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; and 8St Jude Children's Research Hospital, Memphis, Tennessee"}]},{"given":"Anita E.","family":"Grigoriadis","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Section of Paediatric Oncology, The Institute of Cancer Research, and 2Paediatric Oncology, Royal Marsden Hospital, Sutton, United Kingdom; 3Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, and 4Breakthrough Breast Cancer Unit and 5Clinical Neuropathology, Kings College Hospital, London, United Kingdom; 6Life and Health Sciences Research Institute, University do Minho, Braga, Portugal; 7Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; and 8St Jude Children's Research Hospital, Memphis, Tennessee"}]},{"given":"Alan","family":"Ashworth","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Section of Paediatric Oncology, The Institute of Cancer Research, and 2Paediatric Oncology, Royal Marsden Hospital, Sutton, United Kingdom; 3Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, and 4Breakthrough Breast Cancer Unit and 5Clinical Neuropathology, Kings College Hospital, London, United Kingdom; 6Life and Health Sciences Research Institute, University do Minho, Braga, Portugal; 7Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; and 8St Jude Children's Research Hospital, Memphis, Tennessee"}]},{"given":"Rui M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Authors' Affiliations:\u20081Section of Paediatric Oncology, The Institute of Cancer Research, and 2Paediatric Oncology, Royal 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