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A small-molecule compound, Robert Costa Memorial drug-1 (RCM-1), has been recently identified from high-throughput screen as an inhibitor of FOXM1 in vitro and in mouse model of allergen-mediated lung inflammation. In the present study, we examined antitumor activities of RCM-1 using tumor models. Treatment with RCM-1 inhibited tumor cell proliferation as evidenced by increased cell-cycle duration. Confocal imaging of RCM-1\u2013treated tumor cells indicated that delay in cellular proliferation was concordant with inhibition of FOXM1 nuclear localization in these cells. RCM-1 reduced the formation and growth of tumor cell colonies in the colony formation assay. In animal models, RCM-1 treatment inhibited growth of mouse rhabdomyosarcoma Rd76-9, melanoma B16-F10, and human H2122 lung adenocarcinoma. RCM-1 decreased FOXM1 protein in the tumors, reduced tumor cell proliferation, and increased tumor cell apoptosis. RCM-1 decreased protein levels and nuclear localization of \u03b2-catenin, and inhibited protein\u2013protein interaction between \u03b2-catenin and FOXM1 in cultured tumor cells and in vivo. Altogether, our study provides important evidence of antitumor potential of the small-molecule compound RCM-1, suggesting that RCM-1 can be a promising candidate for anticancer therapy.<\/jats:p>","DOI":"10.1158\/1535-7163.mct-18-0709","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T15:35:23Z","timestamp":1556638523000},"page":"1217-1229","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear \u03b2-Catenin"],"prefix":"10.1158","volume":"18","author":[{"given":"Samriddhi","family":"Shukla","sequence":"first","affiliation":[{"name":"1Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio."}]},{"given":"David","family":"Milewski","sequence":"additional","affiliation":[{"name":"1Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital 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