{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T06:40:14Z","timestamp":1654756814983},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"11_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Recently, two mutations (-124G&amp;gt;A and -146G&amp;gt;A) in the promoter region of the telomerase catalytic subunit (TERT) were found in a significant proportion of human tumors, including gliomas, thyroid carcinomas, bladder carcinomas and melanomas. These mutations resulted in increased expression of telomerase, both in vitro and in vivo. In order to further characterize the prevalence of TERT mutations in human tumors, we screened a cohort of 273 human gliomas and found an overall TERT mutation frequency of 50%. TERT mutations were most commonly found in high grade tumors such as glioblastoma multiforme (GBM) and gliosarcoma (65% and 89%, respectively), whereas low grade tumors such as pilocytic astrocytoma and diffuse astrocytoma showed a low frequency of TERT mutations (6% and 16%, respectively). Oligodendrogliomas (grade II) and anaplastic oligodendrogliomas (grade III) also harbored a high frequency of TERT mutations (44% and 52%, respectively). In GBM patients, the presence of TERT mutations was significantly associated with a higher mean age at diagnosis (p&amp;lt;0.0001) and worse survival (p=0.006). Our results show that TERT promoter mutations are frequent in human GBM and oligodendrogliomas and are associated with worse survival in GBM patients.<\/jats:p>\n               <jats:p>Citation Information: Mol Cancer Ther 2013;12(11 Suppl):C118.<\/jats:p>\n               <jats:p>Citation Format: Jorge Lima, Rui M. Reis, Telmo Catarino, Joana Peixoto, Joao Vinagre, Rui Batista, Ligia Castro, Fernando Pardal, Manuel Sobrinho-Simoes, Valdemar Maximo, Paula Soares. TERT promoter mutations in human gliomas. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C118.<\/jats:p>","DOI":"10.1158\/1535-7163.targ-13-c118","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T22:27:17Z","timestamp":1408055237000},"page":"C118-C118","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract C118: TERT promoter mutations in human gliomas."],"prefix":"10.1158","volume":"12","author":[{"given":"Jorge","family":"Lima","sequence":"first","affiliation":[{"name":"1IPATIMUP, Porto, Portugal"}]},{"given":"Rui M.","family":"Reis","sequence":"additional","affiliation":[{"name":"2Life and Health Sciences Research Institute (ICVS), Braga, Portugal"}]},{"given":"Telmo","family":"Catarino","sequence":"additional","affiliation":[{"name":"1IPATIMUP, Porto, Portugal"}]},{"given":"Joana","family":"Peixoto","sequence":"additional","affiliation":[{"name":"1IPATIMUP, Porto, Portugal"}]},{"given":"Joao","family":"Vinagre","sequence":"additional","affiliation":[{"name":"1IPATIMUP, Porto, Portugal"}]},{"given":"Rui","family":"Batista","sequence":"additional","affiliation":[{"name":"1IPATIMUP, Porto, Portugal"}]},{"given":"Ligia","family":"Castro","sequence":"additional","affiliation":[{"name":"3Hospital Sao Joao, Porto, Portugal"}]},{"given":"Fernando","family":"Pardal","sequence":"additional","affiliation":[{"name":"4Hospital de Braga, Braga, Portugal"}]},{"given":"Manuel","family":"Sobrinho-Simoes","sequence":"additional","affiliation":[{"name":"1IPATIMUP, Porto, Portugal"}]},{"given":"Valdemar","family":"Maximo","sequence":"additional","affiliation":[{"name":"1IPATIMUP, Porto, Portugal"}]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[{"name":"1IPATIMUP, Porto, Portugal"}]}],"member":"1086","container-title":["Molecular Cancer Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/mct\/article\/12\/11_Supplement\/C118\/283743\/Abstract-C118-TERT-promoter-mutations-in-human","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/mct\/article\/12\/11_Supplement\/C118\/283743\/Abstract-C118-TERT-promoter-mutations-in-human","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T08:14:18Z","timestamp":1654676058000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/mct\/article\/12\/11_Supplement\/C118\/283743\/Abstract-C118-TERT-promoter-mutations-in-human"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":0,"journal-issue":{"issue":"11_Supplement","published-print":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1535-7163.targ-13-c118","relation":{},"ISSN":["1535-7163","1538-8514"],"issn-type":[{"value":"1535-7163","type":"print"},{"value":"1538-8514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,1]]}}}