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Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P &amp;lt; 10\u22128 seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869\/2q13\/BCL2L11; rs7937840\/11q12\/INCENP; rs1469713\/19p13\/GATAD2A), two breast and ovarian cancer risk loci (rs200182588\/9q31\/SMC2; rs8037137\/15q26\/RCCD1), and two breast and prostate cancer risk loci (rs5013329\/1p34\/NSUN4; rs9375701\/6q23\/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type\u2013specific expression quantitative trait locus and enhancer\u2013gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P &amp;lt; 10\u22125 in the three-cancer meta-analysis.<\/jats:p>\n                  <jats:p>Significance: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. Cancer Discov; 6(9); 1052\u201367. \u00a92016 AACR.<\/jats:p>\n                  <jats:p>This article is highlighted in the In This Issue feature, p. 932<\/jats:p>","DOI":"10.1158\/2159-8290.cd-15-1227","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T20:07:45Z","timestamp":1468872465000},"page":"1052-1067","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":180,"title":["Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types"],"prefix":"10.1158","volume":"6","author":[{"given":"Siddhartha P.","family":"Kar","sequence":"first","affiliation":[{"name":"1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK."}]},{"given":"Jonathan","family":"Beesley","sequence":"additional","affiliation":[{"name":"2Department of Genetics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia."}]},{"given":"Ali","family":"Amin Al Olama","sequence":"additional","affiliation":[{"name":"1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK."}]},{"given":"Kyriaki","family":"Michailidou","sequence":"additional","affiliation":[{"name":"1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK."}]},{"given":"Jonathan","family":"Tyrer","sequence":"additional","affiliation":[{"name":"3Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK."}]},{"given":"ZSofia","family":"Kote-Jarai","sequence":"additional","affiliation":[{"name":"4The Institute of Cancer Research, Sutton, UK."}]},{"given":"Kate","family":"Lawrenson","sequence":"additional","affiliation":[{"name":"5Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California."}]},{"given":"Sara","family":"Lindstrom","sequence":"additional","affiliation":[{"name":"6Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts."}]},{"given":"Susan J.","family":"Ramus","sequence":"additional","affiliation":[{"name":"5Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California."}]},{"given":"Deborah J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK."}]},{"name":"ABCTB Investigators","sequence":"additional","affiliation":[]},{"given":"Adam S.","family":"Kibel","sequence":"additional","affiliation":[{"name":"8Division of Urologic Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts."}]},{"given":"Agnieszka","family":"Dansonka-Mieszkowska","sequence":"additional","affiliation":[{"name":"9Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland."}]},{"given":"Agnieszka","family":"Michael","sequence":"additional","affiliation":[{"name":"10The University of Surrey, Guildford, UK."}]},{"given":"Aida K.","family":"Dieffenbach","sequence":"additional","affiliation":[{"name":"11Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany."},{"name":"12German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"Aleksandra","family":"Gentry-Maharaj","sequence":"additional","affiliation":[{"name":"13Women's Cancer, Institute for Women's Health, University College London, London, UK."}]},{"given":"Alice 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Oncology, University of Sheffield, Sheffield, UK."}]},{"given":"Anja","family":"Rudolph","sequence":"additional","affiliation":[{"name":"19Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}]},{"given":"Anna","family":"Gonzalez-Neira","sequence":"additional","affiliation":[{"name":"20Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO) and Spanish National Genotyping Center (CEGEN), Madrid, Spain."}]},{"given":"Anna H.","family":"Wu","sequence":"additional","affiliation":[{"name":"5Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California."}]},{"given":"Annika","family":"Lindblom","sequence":"additional","affiliation":[{"name":"21Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden."}]},{"given":"Anthony","family":"Swerdlow","sequence":"additional","affiliation":[{"name":"22Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK."},{"name":"23Division of Breast Cancer Research, The Institute of Cancer Research, London, UK."}]},{"name":"AOCS Study Group & Australian Cancer Study (Ovarian Cancer)","sequence":"additional","affiliation":[]},{"name":"APCB BioResource","sequence":"additional","affiliation":[]},{"given":"Argyrios","family":"Ziogas","sequence":"additional","affiliation":[{"name":"27Department of Epidemiology, UCI Center for Cancer Genetics Research and Prevention, School of Medicine, University of California, Irvine, Irvine, California."}]},{"given":"Arif B.","family":"Ekici","sequence":"additional","affiliation":[{"name":"28University Hospital Erlangen, Institute of Human Genetics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany."}]},{"given":"Barbara","family":"Burwinkel","sequence":"additional","affiliation":[{"name":"29Molecular Epidemiology Group, German Cancer 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Huyssens-Stiftung\/Knappschaft GmbH, Essen, Germany."},{"name":"67Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany."}]},{"given":"Francesmary","family":"Modugno","sequence":"additional","affiliation":[{"name":"68Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania."},{"name":"69Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania."},{"name":"70Women's Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania."}]},{"given":"Freddie C.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"71Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK."},{"name":"72Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, 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