{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"American Association for Cancer Research"}],"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:44:44Z","timestamp":1764161084353,"version":"3.46.0"},"posted":{"date-parts":[[2023,6,2]]},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<p>Origins of ncMAPs. <b>A,<\/b> Peptide length distribution of canonical (dark gray) and noncanonical (light gray) MAPs. <b>B,<\/b> Annotation of ncMAPs across gene features. <b>C,<\/b> Analysis of ncMAPs that could originate from nORF. Upstream start codons of noncanonical MAPs are analyzed for their potential to initiate translation and produce ORFs (left-hand side) as a source of ncMAPs. The frequencies of different start codons for positively predicted TIS are shown on the right-hand side. <b>D,<\/b> Analysis of ncMAPs from intronic regions that may originate from IR events. Translation of MAPs from IR sources should be in-frame with the corresponding upstream exons. <b>E,<\/b> Analysis of ncMAPs that could originate from frameshift mutations in cancer. ncMAPs are aligned to an in-silico translated protein database of COSMIC somatic frameshift mutations. <b>F,<\/b> Summary indicating whether the ncMAPs can be accounted for by any of the analyses conducted in panels <b>C<\/b>, <b>D<\/b>, or <b>E<\/b>.<\/p><\/jats:p>","DOI":"10.1158\/2326-6066.23283471","type":"posted-content","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T10:19:45Z","timestamp":1685701185000},"source":"Crossref","is-referenced-by-count":0,"title":["Figure 5 from The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I\u2013Associated Peptides"],"prefix":"10.1158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3086-3742","authenticated-orcid":false,"given":"Georges","family":"Bedran","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-4966","authenticated-orcid":false,"given":"Hans-Christof","family":"Gasser","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-7793","authenticated-orcid":false,"given":"Kenneth","family":"Weke","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-156X","authenticated-orcid":false,"given":"Tongjie","family":"Wang","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-2493","authenticated-orcid":false,"given":"Dominika","family":"Bedran","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-025X","authenticated-orcid":false,"given":"Alexander","family":"Laird","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-7824","authenticated-orcid":false,"given":"Christophe","family":"Battail","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-3596","authenticated-orcid":false,"given":"Fabio Massimo","family":"Zanzotto","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1847-9393","authenticated-orcid":false,"given":"Catia","family":"Pesquita","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-5043","authenticated-orcid":false,"given":"H\u00e5kan","family":"Axelson","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3765-3075","authenticated-orcid":false,"given":"Ajitha","family":"Rajan","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9041-9988","authenticated-orcid":false,"given":"David J.","family":"Harrison","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3140-8469","authenticated-orcid":false,"given":"Aleksander","family":"Palkowski","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-7262","authenticated-orcid":false,"given":"Maciej","family":"Pawlik","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-3369","authenticated-orcid":false,"given":"Maciej","family":"Parys","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-7137","authenticated-orcid":false,"given":"J. 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