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However, the role of this protumoral N-glycan in immune evasion and whether its removal contributes to enhancement of immune recognition and to unleashing an antitumor immune response remain elusive. We demonstrated that branched N-glycans are used by colorectal cancer cells to escape immune recognition, instructing the creation of immunosuppressive networks through inhibition of IFN\u03b3. The removal of this \u201cglycan-mask\u201d exposed immunogenic mannose glycans that potentiated immune recognition by DC-SIGN\u2013expressing immune cells, resulting in an effective antitumor immune response. We revealed a glycoimmune checkpoint in colorectal cancer, highlighting the therapeutic efficacy of its deglycosylation to potentiate immune recognition and, thus, improving cancer immunotherapy.<\/jats:p>","DOI":"10.1158\/2326-6066.cir-20-0264","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T14:36:23Z","timestamp":1600180583000},"page":"1407-1425","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression"],"prefix":"10.1158","volume":"8","author":[{"given":"Mariana C.","family":"Silva","sequence":"first","affiliation":[{"name":"1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal."},{"name":"2Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal."}]},{"given":"\u00c2ngela","family":"Fernandes","sequence":"additional","affiliation":[{"name":"1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal."}]},{"given":"Maria","family":"Oliveira","sequence":"additional","affiliation":[{"name":"1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal."}]},{"given":"Carlos","family":"Resende","sequence":"additional","affiliation":[{"name":"1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal."}]},{"given":"Alexandra","family":"Correia","sequence":"additional","affiliation":[{"name":"1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal."},{"name":"2Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal."}]},{"given":"Julio C.","family":"de-Freitas-Junior","sequence":"additional","affiliation":[{"name":"3Cellular and Molecular Oncobiology 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