{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:09:47Z","timestamp":1760897387843,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>Polymicrobial infections with aerobes and anaerobes are common in female genital tract infections. We evaluated the efficacy of an injectable new quinolone, pazufloxacin, using a uterine endometritis model. Rats were infected with a mixed inoculation of &lt;i&gt;Escherichia coli&lt;\/i&gt; plus &lt;i&gt;Bacteroides fragilis&lt;\/i&gt; (MIC of pazufloxacin and ceftazidime: &lt;i&gt;E.\u00a0coli:&lt;\/i&gt; 0.05 and 1.56\u00a0\u00b5g\/ml, respectively, &lt;i&gt;B.\u00a0fragilis:&lt;\/i&gt; 3.13 and 3.13\u00a0\u00b5g\/ml, respectively). After inoculating 10&lt;sup&gt;7&lt;\/sup&gt;\u00a0cfu\/rat of each organism, pazufloxacin or ceftazidime (10 or 20\u00a0mg\/kg, respectively, i.v., b.i.d., 3 days) was administered and compared with the nontreated group. The viable cell counts of the uterine corpus and uterine cervix in pazufloxacin-treated and ceftazidime-treated groups were decreased, compared with the nontreated group. The viable cell counts of the adnexa in the pazufloxacin-treated group were significantly decreased, compared with the ceftazidime-treated group. These results suggest that pazufloxacin would be useful for the treatment of polymicrobial infections, especially adnexitis.<\/jats:p>","DOI":"10.1159\/000007099","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"99-102","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic Effects of an Injectable New Quinolone, Pazufloxacin, against Polymicrobial Infections in the Uterine Endometritis Model"],"prefix":"10.1159","volume":"44","author":[{"given":"Hiroshige","family":"Mikamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Kawazoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Tamaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-4399(92)90091-M"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:37:48Z","timestamp":1745469468000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000007099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":1,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000007099","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[1998]]}}}