{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:00:12Z","timestamp":1775232012445,"version":"3.50.1"},"reference-count":1,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>&lt;i&gt;Enterococcus faecalis&lt;\/i&gt; plays an important role as a pathogen in polymicrobial infections. We evaluated the efficacy of cefozopran (CZOP) using polymicrobial pyometra rats. Rats were infected with a mixed intrauterine inoculation of &lt;i&gt;E.\u00a0faecalis&lt;\/i&gt; plus either &lt;i&gt;Bacteroides fragilis&lt;\/i&gt; or &lt;i&gt;Prevotella bivia&lt;\/i&gt; (minimal inhibitory concentration of CZOP; &lt;i&gt;E.\u00a0faecalis:&lt;\/i&gt; 6.25 \u00b5g\/ml, &lt;i&gt;B.\u00a0fragilis:&lt;\/i&gt; 12.5 \u00b5g\/ml, &lt;i&gt;P.\u00a0bivia:&lt;\/i&gt; 12.5 \u00b5g\/ml). Immediately after inoculating 10&lt;sup&gt;5&lt;\/sup&gt; CFU of each organism\/rat, CZOP (either 40 mg\/kg, i.v., q.i.d., for 5 days or 80 mg\/kg, i.v., b.i.d., for 5 days) was administered. The intrauterine inflammatory change and bacterial counts in the CZOP-treated group were compared with those in the nontreated control group. CZOP significantly (p &lt; 0.01) decreased the bacterial counts except for &lt;i&gt;B.\u00a0fragilis&lt;\/i&gt; in the regimen of 80 mg\/kg b.i.d. However, the 40 mg\/kg, q.i.d., regimen significantly (p &lt; 0.05) reduced bacterial counts compared to 80 mg\/kg, b.i.d. These results suggest that CZOP in a more divided dose is efficacious for the treatment of polymicrobial infections associated with &lt;i&gt;E. faecalis&lt;\/i&gt; in pyometra.<\/jats:p>","DOI":"10.1159\/000007100","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"103-107","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Effects of Cefozopran on Polymicrobial Infections Associated with Enterococcus faecalis in a Rat Pyometra Model"],"prefix":"10.1159","volume":"44","author":[{"given":"Hiroshige","family":"Mikamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Kawazoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Tamaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.142.11.2006"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:37:48Z","timestamp":1745469468000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000007100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":1,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000007100","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998]]}}}