{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T13:44:03Z","timestamp":1752673443392,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>The in vitro activity of levofloxacin was investigated against 256 clinical strains of four gram-positive genera (&lt;i&gt;Staphylococcus&lt;\/i&gt;, &lt;i&gt;Streptococcus&lt;\/i&gt;, &lt;i&gt;Enterococcus&lt;\/i&gt;, and &lt;i&gt;Listeria&lt;\/i&gt;). Ofloxacin and ciprofloxacin were used as comparators. Uniform susceptibility to levofloxacin was recorded among methicillin-susceptible staphylococci, streptococci other than &lt;i&gt;Streptococcus agalactiae&lt;\/i&gt;, regardless of their being susceptible, intermediate, or resistant to penicillin (&lt;i&gt;S.\u00a0pneumoniae&lt;\/i&gt;) or erythromycin (&lt;i&gt;S.\u00a0pyogenes&lt;\/i&gt; and &lt;i&gt;S.\u00a0pneumoniae&lt;\/i&gt;), in enterococci other than &lt;i&gt;Enterococcus faecalis&lt;\/i&gt; and &lt;i&gt;E.\u00a0faecium&lt;\/i&gt;, and in &lt;i&gt;Listeria monocytogenes&lt;\/i&gt; isolates. Moreover, 1 of 22 &lt;i&gt;S.\u00a0agalactiae&lt;\/i&gt; isolates and 1 of 19 &lt;i&gt;E.\u00a0faecium&lt;\/i&gt; isolates was resistant, and 2 of 19 were intermediate. Resistances to levofloxacin with MIC90s in the resistance range were only observed in methicillin-resistant staphylococci and &lt;i&gt;E.\u00a0faecalis&lt;\/i&gt; isolates. In any case, the MICs of ofloxacin and ciprofloxacin were usually 2\u20134 times higher than those of levofloxacin. In time-kill assays using three test strains (a methicillin-susceptible &lt;i&gt;Staphylococcus aureus&lt;\/i&gt; isolate, a penicillin-susceptible &lt;i&gt;Streptococcus pneumoniae&lt;\/i&gt; isolate, and an &lt;i&gt;E.\u00a0faecalis&lt;\/i&gt; isolate), the bactericidal activity of levofloxacin was greater than that of ciprofloxacin.<\/jats:p>","DOI":"10.1159\/000007234","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"411-417","source":"Crossref","is-referenced-by-count":21,"title":["In vitro Activity of Levofloxacin against Gram-Positive Bacteria"],"prefix":"10.1159","volume":"45","author":[{"given":"Maria Pia","family":"Montanari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Mingoia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro Emanuele","family":"Varaldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,11,11]]},"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:38:48Z","timestamp":1745469528000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000007234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000007234","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[1999]]}}}