{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:10:07Z","timestamp":1745471407346,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>The incidence of opportunistic fungal infections has recently been increasing in many clinical fields. Fluconazole is commonly used against systemic fungal infections. The present study was undertaken to investigate the current status and the efficacy of fluconazole in pelvic fungal gynecological infections. Thirty-eight patients aged 36\u201372 years old diagnosed with pelvic peritonitis with positive fungal culture in pelvic ascites were enrolled in this study and given fluconazole treatment. Forty-two pathogens were isolated from the 38 assessable patients. The predominant pathogen was &lt;i&gt;Candida albicans&lt;\/i&gt; with an incidence of 61.9% (26\/42). Others included non-&lt;i&gt;albicans Candida&lt;\/i&gt; species amounting to 38.1% (16\/42): 19.0% (8\/42) &lt;i&gt;Candida glabrata&lt;\/i&gt;, 7.1% (3\/42) &lt;i&gt;Candida tropicalis&lt;\/i&gt;, 7.1% (3\/42) &lt;i&gt;Candida parapsilosis&lt;\/i&gt; and 4.8% (2\/42) &lt;i&gt;Candida krusei&lt;\/i&gt;. The clinical cure rate at the end of fluconazole treatment was assessed as 30\/38 (78.9%), and the fungal eradication rate as 26\/42 (61.9%). Each rate was 29\/38 (76.3%) and 26\/42 (61.9%), respectively, at 1\u00a0week after the treatment, while the eradication rate of &lt;i&gt;C.\u00a0albicans&lt;\/i&gt; and non-&lt;i&gt;albicans&lt;\/i&gt; species was 20\/26 (76.9%) and 6\/16 (37.5%), respectively. There was no adverse effect exept for slight elevations of GOT, GPT and LDH observed in 1\u00a0patient (2.6%), which returned to normal after the treatment. It seems there may be an increasing trend of non-&lt;i&gt;albicans&lt;\/i&gt; species in pelvic fungal gynecological infection, against which fluconazole appears to be rather effective.<\/jats:p>","DOI":"10.1159\/000007281","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"209-212","source":"Crossref","is-referenced-by-count":6,"title":["Current Status and Fluconazole Treatment of Pelvic Fungal Gynecological Infections"],"prefix":"10.1159","volume":"46","author":[{"given":"Hiroshige","family":"Mikamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoh","family":"Hayasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Tamaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.155.22.2429"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411173312001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000007136"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:39:02Z","timestamp":1745469542000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000007281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":3,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000007281","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2000]]}}}