{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:34:25Z","timestamp":1761154465432,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[1998]]},"abstract":"<b>Background:<\/b> <i>Helicobacter pylori<\/i> is now recognised to be the major cause of antral gastritis and a risk factor for further development of gastric cancer. This infection results in local inflammation and a modification of gastric mucosal epithelial cell characteristics. Systematic investigation for the expression of the secretory component by gastric epithelium in a personal historical series of biopsy specimens showed the expression of this activation marker in 38% of the cases, 19% also showing clear signs of <i>H. pylori<\/i> infection. <b>Aims:<\/b> To further appreciate the activation of epithelial cells in the chronic gastric inflammation associated with <i>H. pylori<\/i> infection and other types of gastritis without consideration of the grade of gastritis. <b>Methods:<\/b> Punch gastric biopsies from 36 patients (10 patients with confirmed <i>H. pylori<\/i> gastritis, 16 patients with non-<i>H. pylori<\/i> gastritis and 10 controls) were tested for the expression of ICAM-1\/CD54, HLA-DP, -DQ, -DR, secretory component and bcl-2 by immunofluorescence. <b>Results:<\/b> Up-regulation of most markers was observed both in <i>H. pylori<\/i> and non-<i>H. pylori<\/i> gastritis, although secretory component, CD54 and DP expression was more closely associated with <i>H. pylori<\/i> gastritis. <b>Conclusion:<\/b> <i>H. pylori<\/i> infection appears to activate gastric epithelial cells more strongly than other types of gastritis. This suggests an active relationship between this bacterium and epithelial cells. Investigation of the up-regulationship between this bacterium and epithelial cells. Investigation of the up-regulation of secretory component, ICAM-1\/CD54 or DP in gastric biopsies may serve as extensive markers in search of <i>H. pylori<\/i> gastric infections.<\/jats:p>","DOI":"10.1159\/000007467","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"53-59","source":"Crossref","is-referenced-by-count":15,"title":["Activation of Epithelial Cells in Gastritis"],"prefix":"10.1159","volume":"59","author":[{"given":"J.","family":"El Kaissouni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Bene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.C.","family":"Faure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,1,8]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1183\/09031936.94.07122226"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1006\/clin.1996.0074"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016\/0140-6736(93)90938-D"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1006\/bbrc.1993.2239"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016\/0092-8674(86)90362-4"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1084\/jem.178.2.427"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:39:11Z","timestamp":1745469551000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000007467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1998,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000007467","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[1998]]}}}