{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:45:25Z","timestamp":1773099925516,"version":"3.50.1"},"reference-count":2,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[1999]]},"abstract":"<i>Background:<\/i> Human anisakidosis is a parasitic disease whose intestinal form shares several characterictics with Crohn\u2019s disease (CD), like the ileocolonic location predominantly and the presence of granuloma. <i>Methods:<\/i> 73 CD patients diagnosed according to Lennard-Jones\u2019 criteria were studied. The disease activity was measured by means of Harvey-Bradshaw Index. Different clinical variables were analyzed. Antigenic extract of <i>Anisakis simplex<\/i> larvae extracted from blue whiting was prepared. Determination of IgG, IgM, IgA and total specific immunoglobulin against <i>A.\u00a0simplex<\/i> were carried out in sera by enzyme-linked immunosorbent assay. Immunorecognition patterns of these sera were realized by immunoblotting analysis. Results were compared with prevalence of antibodies anti-<i>Anisakis<\/i> in 251 healthy controls. <i>Results:<\/i> 29% of CD patients showed detectable specific total Ig (G+M+A) against <i>A.\u00a0simplex<\/i> (95% CI, 19\u201341). For IgG, IgM and IgA the percentages were 44, 18 and 53% (95% CI, 32\u201356, 10\u201326, and 41\u201365) respectively. In positive specific total Ig cases CD was localized mainly in ileum. In IgG-, IgM- and IgA-positive cases the location was predominantly ileocolonic. CD activity index was higher for groups with positive IgA (2.86 vs. 5.55; p < 0.05). <i>Conclusion:<\/i> Patients with CD have high prevalence of specific immunoglobulin against <i>A.\u00a0simplex<\/i>. Specific IgA are associated to higher activity index of CD.<\/jats:p>","DOI":"10.1159\/000007668","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"268-273","source":"Crossref","is-referenced-by-count":9,"title":["Anti-<i>Anisakis<\/i> Antibodies in the Clinical Course of Crohn\u2019s Disease"],"prefix":"10.1159","volume":"60","author":[{"given":"Raquel","family":"Guill\u00e9n-Bueno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Guti\u00e9rrez-Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jes\u00fas","family":"Perteguer-Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Olveira-Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Fernandez-Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Pozuelo-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Cu\u00e9llar","family":"del Hoyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1281"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01000-1"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/7668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:40:38Z","timestamp":1745469638000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000007668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":2,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1999,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000007668","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999]]}}}