{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:11:08Z","timestamp":1790993468861,"version":"4.1.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>In order to address an age-dependent alteration in the concentration of \u03b2-amyloid polypeptides (A\u03b2s) within the central nervous system and its probable predisposition to amyloidgenesis in Alzheimer\u2019s disease (AD), we measured two species of soluble A\u03b2s, A\u03b240 and A\u03b242, in cerebrospinal fluids (CSF) from randomly selected Japanese control subjects at various ages (n = 33) and then compared these data with those of probable Japanese AD patients (n = 23). CSF concentrations of A\u03b240 and A\u03b242 peptides were age-dependent (ANOVA, Bonferroni\u2019s multiple comparison; p &lt; 0.01 and p &lt; 0.05, respectively) and were lower in the infant than in adults. From mid-20, the A\u03b240 concentrations were decreasing while A\u03b242 were rather stable. A\u03b2s in CSF from AD patients (n = 23), whose \u03b54 allele frequency of the apolipoprotein E gene was higher than in controls (n = 83, p &lt; 0.03), were not statistically different from those of age-matched controls (n = 13). A linear relationship was detected between the A\u03b240 concentration and the Mini-Mental State Examination score (p &lt; 0.05). The ratio of the A\u03b242 to the A\u03b240 level measured in the AD CSF samples was approximately 38% decreased compared to age-matched controls (p &lt; 0.05). These data suggest that the physiological metabolism of soluble A\u03b2s in the brain is regulated in an age-dependent manner, and that the ratio of A\u03b242 to A\u03b240 level in the CSF would be a useful marker for monitoring progression of AD.<\/jats:p>","DOI":"10.1159\/000008156","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"155-160","source":"Crossref","is-referenced-by-count":78,"title":["Age-Dependent Change in the Levels of A\u03b240 and A\u03b242 in Cerebrospinal Fluid from Control Subjects, and a Decrease in the Ratio of A\u03b242 to A\u03b240 Level in Cerebrospinal Fluid from Alzheimer\u2019s Disease Patients"],"prefix":"10.1159","volume":"43","author":[{"given":"Ryuichi","family":"Fukuyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Fushiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2000,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91505-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90101-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006976400227"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1995.1080"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1634"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90677-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-864"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80230-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.5.2025"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80244-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1550"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/8156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/8156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:44:53Z","timestamp":1745469893000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000008156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000008156","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000]]}}}