{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:13:59Z","timestamp":1745554439449,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>Intestinal ischaemia-reperfusion and hyperamylinaemia are both associated with severe acute pancreatitis. The aim of this study was to examine the relationship between intestinal-ischaemia reperfusion and plasma amylin in an experimental model. Wistar rats (n = 24, 400\u2013450 g) were divided into three groups: (1)\u00a0a sham (S)-operated group (n = 7) that underwent laparotomy and isolation (without clamping) of the superior mesenteric artery, (2) an ischaemia-reperfusion (IR) group (n = 7) that had clamping of the superior mesenteric artery for 60\u00a0min followed by 15 min reperfusion, and (3) a control (C) group (n = 10) that underwent no surgery. Amylin was significantly elevated in the IR group (median 39\u00a0p&lt;i&gt;M&lt;\/i&gt;, range 30\u201344) compared with the S group (19\u00a0p&lt;i&gt;M&lt;\/i&gt;, range 15\u201345; Mann-Whitney U, p &lt; 0.05) and the C group (24\u00a0p&lt;i&gt;M&lt;\/i&gt;, range 15\u201355; p &lt; 0.01). Insulin was significantly elevated in the IR group (2,060 p&lt;i&gt;M&lt;\/i&gt;, range 1,000\u20134,650) compared with the S group (558\u00a0p&lt;i&gt;M&lt;\/i&gt;, range 424\u20132,020; p &lt; 0.01). There was a significant positive correlation between amylin and insulin (R = 0.82, F = 46.6, p &lt; 0.0001), but not between amylin and glucose or insulin and glucose. Intestinal histology was consistent with an ischaemia-reperfusion injury, whereas pancreatic histology was normal. The unique finding that plasma amylin concentration is increased with intestinal ischaemia-reperfusion injury warrants further investigation.<\/jats:p>","DOI":"10.1159\/000008725","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"457-464","source":"Crossref","is-referenced-by-count":3,"title":["Intestinal Ischaemia-Reperfusion Increases Plasma Amylin Concentration in Rats"],"prefix":"10.1159","volume":"31","author":[{"given":"A.R.J.","family":"Phillips","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikri M.","family":"Abu-Zidan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.D.","family":"Bonham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misho O.","family":"Simovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.S.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Windsor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/335632a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)81113-M"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/8725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/8725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:47:09Z","timestamp":1745470029000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000008725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":2,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000008725","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[1999]]}}}