{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T10:46:12Z","timestamp":1763808372510,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>The aim of this study was to evaluate the ovarian cysts appearing during GnRH-a\/hMG treatment in patients with polycystic ovarian syndrome (PCOS). A total of 35 women with PCOS were included in the study. All women received 3.75\u00a0mg IM of long-acting leuprolide acetate on the first day of the menstrual cycle. On the 15th day of the menstrual cycle, transvaginal ultrasound examination (US) and determination of serum E&lt;sub&gt;2&lt;\/sub&gt; were done. A total of 90 cycles were studied in this way and during these cycles, 14 (15.5%) ovarian cysts with a diameter of \u2265 20\u00a0mm developed. According to the serum E&lt;sub&gt;2&lt;\/sub&gt; levels, 11 cases (group A) had E&lt;sub&gt;2&lt;\/sub&gt; concentrations &gt; 35\u00a0pg\/ml and 3 (group B) had serum E&lt;sub&gt;2&lt;\/sub&gt; levels &lt; 35\u00a0pg\/ml. Group A patients attained a significantly larger mean size of ovarian cyst than group B patients (42 \u00b1 7.3 vs. 24.2 \u00b1 3.2\u00a0mm, p &lt; 0.001). When the serum E&lt;sub&gt;2&lt;\/sub&gt; concentrations were &lt; 35\u00a0pg\/ml, the ovarian cysts were disregarded and ovarian stimulation with gonadotropins was initiated. In case that serum E&lt;sub&gt;2&lt;\/sub&gt; levels were &gt; 35\u00a0pg\/ml, the initiation of the ovarian stimulation with hMG was postponed until serum E&lt;sub&gt;2&lt;\/sub&gt; levels indicated down-regulation, which was achieved after 5.8 \u00b1 2.9\u00a0days. In both groups the ovarian stimulation resulted in ovulatory cycles, while four pregnancies in group A and one in group B were achieved. In conclusion, our results indicate that in patients with PCOS the GnRH-a administration may cause follicular cysts at an incidence of 15.5%. These cysts do not constitute a contraindication for ovarian stimulation provided that serum E&lt;sub&gt;2&lt;\/sub&gt; levels are low.<\/jats:p>","DOI":"10.1159\/000010044","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:42:49Z","timestamp":1050421369000},"page":"252-255","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Ovarian Cysts following GnRH-a Treatment in Patients with Polycystic Ovarian Syndrome"],"prefix":"10.1159","volume":"46","author":[{"given":"O.","family":"Gregoriou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Vitoratos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Konidaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Papadias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chryssikopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,11,18]]},"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/10044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/10044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:49:21Z","timestamp":1745470161000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000010044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1998,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000010044","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[1998]]}}}