{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:14Z","timestamp":1760244914159,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>Novel human estrogen receptor (ER)-\u03b2 was identified in cDNA libraries from human testis. ER-\u03b2 specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-\u03b2 might not conserve the same physiological functions as does ER-\u03b1. Therefore, the clinical significance of the expression of ER-\u03b1 and ER-\u03b2 mRNAs in ovarian cancers was investigated. The percentage of ER-\u03b2 mRNA to ER-\u03b1 mRNA ranged from 1.5 to 10% in normal ovaries. On the other hand, the ratios of ER-\u03b2 mRNA to ER-\u03b1 mRNA were in a wide range in ovarian cancers. There was no significant difference in the ratios among ovarian cancers classified according to histological types or clinical stages. In a 48-month survival rate, the patient prognosis in ovarian cancers with a low or high ratio of ER-\u03b2 mRNA to ER-\u03b1 mRNA (&lt;1.5 or &gt;10% of ER-\u03b2 mRNA to ER-\u03b1 mRNA) was significantly worse than that in ovarian cancers with a medium ratio (\u22671.5 to \u226610% of ER-\u03b2 mRNA to ER-\u03b1 mRNA). In conclusion, the intact synchronized expression of ER-\u03b2 mRNA interacting with ER-\u03b1 mRNA might be damaged in some ovarian cancers, which might lead to poor patient prognosis.<\/jats:p>","DOI":"10.1159\/000012121","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:43:24Z","timestamp":1050421404000},"page":"334-341","source":"Crossref","is-referenced-by-count":25,"title":["Clinical Significance of Expression of Estrogen Receptor \u03b1 and \u03b2 mRNAs in Ovarian Cancers"],"prefix":"10.1159","volume":"58","author":[{"given":"Jiro","family":"Fujimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Tamaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81118-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90199-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5925"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.3.863"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/me.11.3.353"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5331.1508"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.10.3509"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.11.4796"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1476"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.11.4613"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1987.9999"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(90)90020-S"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/12121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/12121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:37Z","timestamp":1745470597000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000012121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2000,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000012121","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2000]]}}}