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Both a computerized (Medline) and a manual search of the literature were performed. In a substantial proportion of patients with panic disorder with agoraphobia a prodromal phase can be identified. Most patients report residual symptoms despite successful treatment. Residual symptoms upon remission have a prognostic value. There appears to be a relationship between residual and prodromal symptomatology (the rollback phenomenon). Appraisal of subclinical symptomatology in panic disorder has important implications as to the pathophysiological model of disease, its conceptualization and treatment.<\/jats:p>","DOI":"10.1159\/000012345","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:43:24Z","timestamp":1050421404000},"page":"281-289","source":"Crossref","is-referenced-by-count":53,"title":["Subclinical Symptoms of Panic Disorder: New Insights into Pathophysiology and Treatment"],"prefix":"10.1159","volume":"68","author":[{"given":"Giovanni A.","family":"Fava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Mangelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798007429"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.7.2647"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000012274"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-3514.57.6.1069"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000012297"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000012329"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(90)90020-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(85)90014-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000012262"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(81)90040-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(88)90040-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(85)90108-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(85)90178-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(92)90038-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199702000-00012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0887-6185(88)90027-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(89)90080-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-006X.63.5.754"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(88)90034-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(91)90023-L"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(91)90085-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199609000-00009"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(90)90030-T"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199606000-00007"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(86)90011-2"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.153.18.2093"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291797006363"}],"container-title":["Psychotherapy and Psychosomatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/12345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/12345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:24Z","timestamp":1745470704000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000012345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000012345","archive":["Portico"],"relation":{},"ISSN":["0033-3190","1423-0348"],"issn-type":[{"type":"print","value":"0033-3190"},{"type":"electronic","value":"1423-0348"}],"subject":[],"published":{"date-parts":[[1999]]}}}