{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:14:41Z","timestamp":1745554481249,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>Some contributions: (1)\u00a0urinary urea, its chemical composition and physiological meaning, Fourcroy and Vauquelin (1790\u20131808); (2)\u00a0in binephrectomized animals blood urea is high and chemically identical to that of urine, Prevost and Dumas (1821); (3)\u00a0urea level in renal vein blood is 50% of that in the arteries, Picard (1856); (4)\u00a0retained potassium is the uremic poison, Feltz and Ritter (1881); (5)\u00a0polyuria induced by intravenous injections of sugars or urea, Richet and Moutard Martin (1880); is the kidney in command of the concentration of the blood? Using cryoscopy, H\u00e9don got the clue, the osmotic load (1900); (6)\u00a0methylene dye excretion measures the global renal function and thus the degree of renal failure, Achard and Castaigne (1897); (7)\u00a0the disentanglement of chronic uremia and edema, Widal and Achard (1900\u20131910); (8)\u00a0evaluation of the global renal function by the ratio plasma urea\/urine urea output, Ambard\u2019s Constant (1905), initial step of the concept of clearance; (9)\u00a0a circulating nephropoietic factor in one-kidney animals, Carnot (1910). In bled animals he also disclosed a hemopoietic factor which later became the renal erythropoietin.<\/jats:p>","DOI":"10.1159\/000013461","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:43:24Z","timestamp":1050421404000},"page":"274-281","source":"Crossref","is-referenced-by-count":4,"title":["The Contribution of French-SpeakingScientists to the Origins of Renal Physiologyand Pathophysiology (1790\u20131910)"],"prefix":"10.1159","volume":"19","author":[{"given":"Gabriel","family":"Richet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,4,23]]},"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/13461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/13461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:03:37Z","timestamp":1745471017000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000013461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000013461","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"type":"print","value":"0250-8095"},{"type":"electronic","value":"1421-9670"}],"subject":[],"published":{"date-parts":[[1999]]}}}