{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:10:25Z","timestamp":1793041825831,"version":"4.5.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>Reactive oxygen species (ROS) have been implicated in a growing number of neurological disease states, from acute traumatic injury to neurodegenerative conditions such as Alzheimer\u2019s disease. Considerable evidence suggests that ROS also mediate ototoxicant- and noise-induced cochlear injury, although most of this evidence is indirect. To obtain real-time assessment of noise-induced cochlear ROS production in vivo, we adapted a technique which uses the oxidation of salicylate to 2,3-dihydroxybenzoic acid as a probe for the generation of hydroxyl radical. In a companion paper we described the development and characterization of this method in cochlear ischemia-reperfusion. In the present paper we use this method to demonstrate early elevations in ROS production following acute noise exposure. C57BL\/6J mice were exposed for 1\u00a0h to intense broad-band noise sufficient to cause permanent threshold shift (PTS), as verified by auditory brainstem responses. Comparison of noise-exposed animals with unexposed controls indicated that ROS levels increase nearly 4-fold in the period 1\u20132\u00a0h following exposure and do not decline over that time. Our ROS measures extend previous results indicating that noise-induced PTS is associated with elevated cochlear ROS production and ROS-mediated injury. Persistent cochlear ROS elevation following noise exposure suggests a sustained process of oxidative stress which might be amenable to intervention with chronic antioxidant therapy.<\/jats:p>","DOI":"10.1159\/000013846","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T11:43:24Z","timestamp":1050407004000},"page":"229-236","source":"Crossref","is-referenced-by-count":360,"title":["Early Elevation of Cochlear Reactive Oxygen Species following Noise Exposure"],"prefix":"10.1159","volume":"4","author":[{"given":"Kevin K.","family":"Ohlemiller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Dugan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1999,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90132-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(96)00075-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(95)00226-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(89)90065-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(92)90070-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(96)00169-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00155-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1995.1099"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000013845"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000013846"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)90189-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01090-6"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/13846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/13846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:06:23Z","timestamp":1745456783000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000013846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1999,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000013846","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"value":"1420-3030","type":"print"},{"value":"1421-9700","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999]]}}}