{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:30:41Z","timestamp":1787164241786,"version":"build-2736575974"},"reference-count":4,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>A prospective sequential, multicentre trial was conducted to determine the association between erythropoietin (EPO) plasma levels and the erythropoietic response to recombinant human erythropoietin (r-HuEPO) during long-term treatment of premature infants. Twenty-nine infants, gestational ages 26\u201334 weeks and postnatal ages more than 14 days, received 600\u00a0IU r-HuEPO per kg per week divided into three doses subcutaneously for haemoglobin levels less than 120\u00a0g\/l or haematocrit less than 36% over a period of 4 weeks. Eight additional patients were studied for a total of 10 weeks. EPO plasma concentrations and haematologic parameters were measured prior to the onset of treatment and at 2-weekly intervals thereafter. Treatment with r-HuEPO resulted in a median increase in corrected reticulocyte counts of 2.5% (range 0.2\u20134.6%) above patient\u2019s baseline, thereafter a decrease was observed. In the 8 patients followed for 10 weeks reticulocyte counts declined significantly during weeks 6\u201310 when compared with the first 4 weeks (p &lt; 0.005). Median 72-hour post-dose EPO plasma levels increased significantly (p &lt; 0.0001) to 57.3\u00a0mU\/ml (range 5.0\u2013160) above patient\u2019s baseline after the first injection, but declined progressively thereafter until they approached baseline values at week 10. &lt;b&gt;Conclusion:&lt;\/b&gt; R-HuEPO treatment after the first month was associated with a decrease in post-injection plasma levels and a decrease in erythropoietic response. This decrease in erythropoietin\u2019s efficacy and the decline observed in post-dose EPO plasma levels may be causally related.<\/jats:p>","DOI":"10.1159\/000014062","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T11:43:24Z","timestamp":1050407004000},"page":"409-415","source":"Crossref","is-referenced-by-count":3,"title":["Decreasing Reticulocyte Counts Associated with Declining Post-Dose Erythropoietin Plasma Levels in Anaemia of Prematurity"],"prefix":"10.1159","volume":"74","author":[{"given":"Bernhard","family":"Meister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August","family":"Khoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Burda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha","family":"Kolmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lischka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Pollak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1998,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404283301709"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404283301701"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09208-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0753-3322(92)90068-I"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:07:19Z","timestamp":1745456839000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000014062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":4,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1998,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000014062","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998]]}}}