{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:49:39Z","timestamp":1761706179731,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1998,12,2]],"date-time":"1998-12-02T00:00:00Z","timestamp":912556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,12,2]],"date-time":"1998-12-02T00:00:00Z","timestamp":912556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[1999]]},"abstract":"Early detection of pathophysiological factors associated with permanent brain damage is a major issue in neonatal medicine. The aim of our study was to evaluate the significance of the CO<sub>2<\/sub> reactivity of cerebral blood flow (CBF) in neonates with perinatal risk factors. Fourteen ventilated neonates with perinatal risk factors (pathological cardiotocogramm, low cord pH, postpartal encephalopathy) were enrolled into this prospective study. The study was performed 18\u2013123\u00a0h after birth. CBF was measured using the nonivasive intravenous <sup>133<\/sup>Xe method. Two measurements were taken with a minimal PaCO<sub>2<\/sub>-difference of 5\u00a0mm Hg. From the two CBF values the CO<sub>2<\/sub> reactivity was calculated. Outcome was evaluated 1 year after birth. The CBF values at a lower PaCO<sub>2<\/sub> ranged from 6.6 to 115.2 ml\/100 g brain issue\/min (median = 18.2) and at a higher PaCO<sub>2<\/sub> level from 7.1 to 125.7 ml\/100 g brain tissue\/min (median = 18.75). The calculated CO<sub>2<\/sub> reactivity ranged from \u20139.6 to 6.6% (median 1.1%) change in CBF\/mm Hg change in PaCO<sub>2<\/sub>. CO<sub>2<\/sub> reactivity correlated with lowest pH (r<sup>2<\/sup> = 0.35, p = 0.02). Two infants died, one of neonatal sepsis, the other of heart failure. Neurological outcome at the age of 1 year was normal in 11 patients, 1 had severe cerebral palsy. From the 12 surviving patients the patient with severe neurological deficit showed \nthe highest CBF values (125.7 ml\/100 g\/min). Impaired chemical coupling of cerebral blood flow is compatible with intact neurological outcome in neonates with perinatal risk factors. CO<sub>2<\/sub> reactivity in these newborns correlates with the lowest pH and may reflect the severity of perinatal asphyxia.<\/jats:p>","DOI":"10.1159\/000014072","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:43:24Z","timestamp":1050421404000},"page":"9-17","source":"Crossref","is-referenced-by-count":7,"title":["Impaired Chemical Coupling of Cerebral Blood Flow Is Compatible with Intact Neurological Outcome in Neonates with Perinatal Risk Factors"],"prefix":"10.1159","volume":"75","author":[{"given":"Oskar","family":"Baenziger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Moenkhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleo G.","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Waldvogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Ulrich","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Fanconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(94)90009-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)00956-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00028-3"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:07:26Z","timestamp":1745471246000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000014072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12,2]]},"references-count":3,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000014072","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[1998,12,2]]}}}