{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:40:03Z","timestamp":1745473203630,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>Newborns possess an altered immune response to infection with impaired leukocyte chemotaxis and deficient production of gamma-interferon (IFN-\u03b3). IFN-\u03b3 enhances neonatal leukocyte activation and movement. We proposed that IFN-\u03b3 in conjunction with penicillin compared to penicillin therapy without IFN-\u03b3 would increase survival from group B streptococcal sepsis in a neonatal rat model. Newborn rats were infected with 10&lt;sup&gt;5&lt;\/sup&gt; cfu of group B streptococci at 48\u201372\u00a0h of age and randomized to receive either serum albumin (controls), rat recombinant IFN-\u03b3, albumin and penicillin, or IFN-\u03b3 and penicillin. Survival 120\u00a0h postinfection revealed: controls 5% (1\/21); IFN-\u03b3 4% (1\/24); penicillin 23% (5\/22); and IFN-\u03b3 plus penicillin 10% (2\/21). Survival analysis with a lognormal parametric regression model revealed only the penicillin group to have improved survival compared to controls. Contrasting the penicillin group with the IFN-\u03b3 plus penicillin group did not reveal a statistically significant difference by the Wald \u03c7&lt;sup&gt;2&lt;\/sup&gt; statistic (p = 0.25).<\/jats:p>","DOI":"10.1159\/000014151","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:43:24Z","timestamp":1050421404000},"page":"125-128","source":"Crossref","is-referenced-by-count":0,"title":["Failure of Gamma-Interferon to Decrease Mortality from Group B Streptococcal Sepsis in Neonatal Rats"],"prefix":"10.1159","volume":"76","author":[{"given":"Robert R.","family":"Wittler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald D.","family":"Paine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,7,9]]},"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:08:09Z","timestamp":1745471289000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000014151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000014151","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[1999]]}}}