{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:38:08Z","timestamp":1790120288734,"version":"4.0.1"},"reference-count":6,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>Sequential changes in plasma endothelin-1 (ET-1) and pulmonary hemodynamics were studied in a piglet model of meconium aspiration syndrome (MAS). Sixteen piglets were randomly divided into meconium (MEC) and normal saline (NS) groups (8 animals\/group). The animals of the MEC group were instilled with meconium (20% in normal saline) via an endotracheal tube (3 ml\/kg), and the animals of the NS group instilled with the same amount of normal saline. The plasma ET-1 as well as pulmonary mechanics, arterial blood gas and hemodynamics were measured at baseline and 60, 120, 180 and 240 min after instillation. The results showed that plasma ET-1 level of the MEC group was significantly higher after meconium aspiration as compared with NS group (p &lt; 0.05 at 60 and 120 min, p &lt; 0.01 at 180 and 240 min). Furthermore, pulmonary vascular resistance (PVR) increased and remained elevated after 120 min (p &lt; 0.01) and pulmonary artery pressure (PAP) increased after 180 min (p &lt; 0.01). The correlation was significant between ET-1 and PVR (r = 0.92, p &lt; 0.001) as well as ET-1 and PAP (r = 0.89, p &lt; 0.001). These data suggest that elevation of ET-1, which has long-lasting vasoconstriction effect, may play an important role of pulmonary hypertension of MAS.<\/jats:p>","DOI":"10.1159\/000014163","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:43:24Z","timestamp":1050421404000},"page":"228-234","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Meconium Aspiration on Plasma Endothelin-1 Level and Pulmonary Hemodynamics in a Piglet Model"],"prefix":"10.1159","volume":"76","author":[{"given":"Chii-Yuh","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1999,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330607"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.18.10855"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90484-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90733-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90387-J"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:08:16Z","timestamp":1745471296000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000014163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":6,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000014163","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999]]}}}