{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:06:00Z","timestamp":1759565160408,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1999,12,9]],"date-time":"1999-12-09T00:00:00Z","timestamp":944697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,12,9]],"date-time":"1999-12-09T00:00:00Z","timestamp":944697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>The pulmonary vascular resistance decreases at birth secondary to release of endothelium-derived nitric oxide (EDNO). EDNO release is a calcium-dependent process, and endothelial potassium (K&lt;sup&gt;+&lt;\/sup&gt;) channels regulate intracellular calcium flux. We investigated the hypothesis that potassium channels mediate oxygen-induced pulmonary vasodilation and EDNO release in fetal lambs. We instrumented 18 near-term fetal lambs at 122\u2013126 days of gestation to measure pulmonary pressures, flow, and resistance. We studied hemodynamic effects of (1) 100% oxygen; (2) pinacidil, an ATP-sensitive K&lt;sup&gt;+&lt;\/sup&gt; (K&lt;sub&gt;ATP&lt;\/sub&gt;) channel agonist, and (3) S-nitroso-N-acetylpenicillamine (SNAP), a NO donor. We studied the effects of glybenclamide, a K&lt;sub&gt;ATP&lt;\/sub&gt; channel antagonist, tetraethylammonium chloride (TEA), a preferential K&lt;sub&gt;Ca&lt;\/sub&gt; channel antagonist, and nitro-&lt;i&gt;L&lt;\/i&gt;-arginine (NLA), an NO synthase inhibitor, on the response to some of the above agents. Oxygen-induced pulmonary vasodilation was inhibited by both glybenclamide and TEA, indicating that K&lt;sub&gt;ATP&lt;\/sub&gt; and K&lt;sub&gt;Ca&lt;\/sub&gt; channels mediate pulmonary vasodilator response to oxygen. Blocking NO synthesis with NLA inhibited pinacidil-mediated pulmonary vasodilation, indicating that K&lt;sub&gt;ATP&lt;\/sub&gt; channel activation stimulates NO release. SNAP-mediated pulmonary vasodilation was inhibited by TEA, but not glybenclamide, indicating that K&lt;sub&gt;Ca&lt;\/sub&gt; channels, but not K&lt;sub&gt;ATP&lt;\/sub&gt; channels, mediate effects of NO on vascular smooth muscle relaxation. In conclusion, K&lt;sup&gt;+&lt;\/sup&gt; channels mediate oxygen-induced pulmonary vasodilation in fetal lambs. K&lt;sub&gt;ATP&lt;\/sub&gt; channels appear to mediate EDNO release, while K&lt;sub&gt;Ca&lt;\/sub&gt; channels probably mediate NO effects on vascular smooth muscle.<\/jats:p>","DOI":"10.1159\/000014196","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:43:24Z","timestamp":1050421404000},"page":"58-68","source":"Crossref","is-referenced-by-count":8,"title":["Vascular Potassium Channels Mediate Oxygen-Induced Pulmonary Vasodilation in Fetal Lambs"],"prefix":"10.1159","volume":"77","author":[{"given":"Seema","family":"Mital","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Ganesh","family":"Konduri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.8089"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-75-10-11-1241"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/14196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:08:37Z","timestamp":1745471317000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000014196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12,9]]},"references-count":2,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000014196","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[1999,12,9]]}}}