{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:22:38Z","timestamp":1778314958739,"version":"3.51.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>The \u03c34 isoform of apolipoprotein E (ApoE) has been proposed as a risk factor for Alzheimer\u2019s disease (AD), while the possible role of the \u03c32 allele in AD is controversial. We have studied the ApoE genotype in 38 patients with early-onset AD (EOAD) and in 43 patients with late-onset AD (LOAD). In the EOAD group we observed a significant increase of \u03c34 allele frequency as compared with normal controls, while there was a more than 3-fold decrease of \u03c32 allele frequency that did not reach statistical significance. In the LOAD group we found a highly significant increase of \u03c34 allele frequency as compared with normal controls, while there was a significant decrease of \u03c32 allele frequency. In both the EOAD and LOAD groups, no significant difference was observed between \u03c34 carriers and \u03c34 noncarriers as for age at disease onset, disease duration, and Mini-Mental State score at observation. However, in both EOAD and LOAD groups a statistical trend towards a longer disease duration was observed in \u03c34 carriers. In both the EOAD and LOAD groups, disease severity was compared in \u03c34 carriers versus \u03c34 noncarriers by means of analyses of covariance, with disease duration as covariate. No significant difference between \u03c34 carriers and \u03c34 noncarriers was observed in both EOAD and LOAD. The results of the present study confirm that \u03c34 allele seems to be associated with an increased risk for sporadic AD, while the significant decrease of \u03c32 allele frequency in the LOAD group supports the hypothesis of a possible protective role of \u03c32 allele in AD.<\/jats:p>","DOI":"10.1159\/000017034","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:25:18Z","timestamp":1050427518000},"page":"121-125","source":"Crossref","is-referenced-by-count":14,"title":["Apolipoprotein E Genotype in Sporadic Early- and Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"9","author":[{"given":"C.","family":"Masullo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Daniele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Seripa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Filippini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gravina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Gainotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.M.","family":"Fazio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-180"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)91074-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90054-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0061"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)01251-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91434-8"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:48:41Z","timestamp":1745470121000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000017034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":7,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1998,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000017034","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998]]}}}