{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:03:37Z","timestamp":1774969417413,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>Apolipoprotein E (apoE) \u03c34 allele is a risk factor for late-onset Alzheimer\u2019s disease (AD) and is proposed to have an impact on cholinergic function in AD. Slowing of the EEG is characteristic in AD and the cholinergic system has an important role in modulating EEG. QEEG was recorded from 31 AD patients at the early stage of the disease and after a 3-year follow-up. AD patients were divided into subgroups according to the apoE \u03c34 allele (2\u03c34, 1\u03c34 and 0\u03c34). AD subgroups did not differ in clinical severity or duration of dementia. The AD patients carrying the \u03c34 allele had more pronounced slow-wave activity than AD patients without the \u03c34 allele, although the progression rate did not change. The differences in EEG may suggest differences in the degree of the cholinergic deficit in these subgroups.<\/jats:p>","DOI":"10.1159\/000017210","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:25:18Z","timestamp":1050427518000},"page":"29-35","source":"Crossref","is-referenced-by-count":41,"title":["A Longitudinal Quantitative EEG Study of Alzheimer\u2019s Disease: Relation to Apolipoprotein E Polymorphism"],"prefix":"10.1159","volume":"11","author":[{"given":"Maarit","family":"Lehtovirta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhani","family":"Partanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervi","family":"K\u00f6n\u00f6nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Helisalmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Hartikainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paavo","family":"Riekkinen Sr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90156-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(89)90064-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(85)91048-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(93)90131-E"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(91)90198-D"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(91)90107-F"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1037\/\/0735-7044.110.6.1235"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(85)90942-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(82)90112-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(94)90144-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90223-O"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90351-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91092-F"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90444-C"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1019"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:50:20Z","timestamp":1745470220000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000017210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000017210","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000]]}}}