{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:05:07Z","timestamp":1789909507117,"version":"4.0.1"},"reference-count":1,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>&lt;b&gt;Background:&lt;\/b&gt; Pilot studies of adjuvant therapy with topically applied interferons (IFN) have shown promising results in reducing the recurrence of condylomata acuminata (CA). &lt;b&gt;Objective:&lt;\/b&gt; The aim of this multicenter placebo-controlled, double-blind study was to confirm the efficacy and safety of topically applied IFN in a large sample of patients. &lt;b&gt;Methods:&lt;\/b&gt; After removal of CA by CO&lt;sub&gt;2&lt;\/sub&gt; laser surgery, electrocautery or cryosurgery, 120 patients applied either recombinant IFN-\u03b2 (0.15 or 1.0 \u00d7 10&lt;sup&gt;6&lt;\/sup&gt; IU\/g) or placebo gel to the affected areas 5 times daily for 4 weeks. The patients were followed for a total of 24 weeks or until recurrence of CA was observed, respectively. &lt;b&gt;Results:&lt;\/b&gt; In the 105 patients evaluated for efficacy after 24 weeks, recurrence rates were 75% (27\/36 patients) in the placebo group, 62% (21\/34) in the 1.0 \u00d7 10&lt;sup&gt;6&lt;\/sup&gt; IU\/g group (n.s.) and 54% (19\/35) in the 0.15 \u00d7 10&lt;sup&gt;6&lt;\/sup&gt; IU\/g group (p = 0.034). Only few mild adverse events were noted, which were almost limited to the application site. &lt;b&gt;Conclusion:&lt;\/b&gt; Topical application of gel containing 0.15 \u00d7 10&lt;sup&gt;6&lt;\/sup&gt; IU\/g recombinant IFN-\u03b2 is safe and appears to reduce the recurrence of CA after surgical treatment.<\/jats:p>","DOI":"10.1159\/000017906","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:25:18Z","timestamp":1050427518000},"page":"330-334","source":"Crossref","is-referenced-by-count":18,"title":["Recombinant Interferon Beta Gel as an Adjuvant in the Treatment of Recurrent Genital Warts: Results of a Placebo-Controlled Double-Blind Study in 120 Patients"],"prefix":"10.1159","volume":"196","author":[{"given":"G.","family":"Gross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Rogozinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sch\u00f6fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jablonska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Roussaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"W\u00f6hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Brzoska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1998,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(94)90067-1"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:53:11Z","timestamp":1745470391000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000017906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":1,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1998,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000017906","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998]]}}}