{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:14:17Z","timestamp":1745554457085,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[1998]]},"abstract":"<b>Background:<\/b> Several studies indicate that immunohistochemical detection of the c-<i>myc<\/i> oncogene might serve as an additional prognostic marker in malignant melanoma. <b>Objective:<\/b> To study c-<i>myc<\/i> expression in paraffin-embedded cutaneous melanoma and to correlate to metastatic potential and onset of metastases. <b>Methods:<\/b> Cytoplasmic c-<i>myc<\/i> protein expression was visualized using the APAPP method, and reactivity (percent total tumor cells stained) was assessed in 62 formalin-fixed paraffin-embedded primary cutaneous melanomas (21 not metastasizing, mean Breslow 3.0 \u00b1 2.9 mm, 41 metastasizing, mean Breslow 3.1 \u00b1 3.0 mm) and 24 metastases of the same patients. <b>Results:<\/b> There was no significant difference of c-<i>myc<\/i> reactivity in cutaneous melanoma who did not metastasize (n = 21, c-<i>myc<\/i> reactivity 32.7 \u00b1 19.3%, follow-up 10.6 \u00b1 1.8 years) and primaries who metastasized (n = 41, c-<i>myc<\/i> reactivity 27.7 \u00b1 22.4%, p = 0.29). This finding was independent of the thickness of the primary and was found within thin cutaneous melanoma with a Breslow <0.75 mm (range 0.24\u20130.65 mm, n = 20, c-<i>myc<\/i> reactivity 29.1 \u00b1 15.7%, p = 0.32) or within thick cutaneous melanoma with a Breslow >1.5 mm (range 1.6\u201311 mm, n = 41, c-<i>myc<\/i> reactivity 29.6 \u00b1 23.8%, p = 0.46). No correlation of c-<i>myc<\/i> expression between thin cutaneous melanoma, thick cutaneous melanoma (p = 0.83) or metastasizing primaries and their metastases (n = 24, c-<i>myc<\/i> reactivity 29.3 \u00b1 22%) was found (p = 0.64). The time period until development of first metastasis did not correlate with the percentage of cells expressing c-<i>myc<\/i> in the primary (p = 0.56). <b>Conclusion:<\/b> c-<i>myc<\/i> expression is independent of metastatic potential and onset of metastases and, therefore, does not serve as a prognostic immunohistochemical marker in primary cutaneous melanoma.<\/jats:p>","DOI":"10.1159\/000017922","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:25:18Z","timestamp":1050427518000},"page":"288-291","source":"Crossref","is-referenced-by-count":11,"title":["c<i>-myc<\/i> Is Not Useful as Prognostic Immunohistochemical Marker in Cutaneous Melanoma"],"prefix":"10.1159","volume":"196","author":[{"given":"R.","family":"B\u00f6ni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Bantschapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Burg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(93)90209-Z"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199701)181:1<75::AID-PATH724>3.3.CO;2-M"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:53:19Z","timestamp":1745470399000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000017922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":2,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1998,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000017922","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[1998]]}}}