{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:47:17Z","timestamp":1787496437541,"version":"build-2736575974"},"reference-count":3,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>&lt;b&gt;Background:&lt;\/b&gt; The aetiopathogenesis of psoriasis is still not fully understood. Recently, it has been reported that prolactin (PRL) exerts a proliferative effect on human keratinocytes in vitro. PRL may, therefore, play an important role in the pathogenesis of psoriasis. &lt;b&gt;Objective:&lt;\/b&gt; To assess the serum PRL level in patients with psoriasis vulgaris (PV). &lt;b&gt;Methods:&lt;\/b&gt; Serum levels of PRL were estimated in 12 patients with PV (age: 11\u201345 years with mean \u00b1 SD 30.4 \u00b1 10.2 years; sex: 7 males, 5 females) and the results were compared with those in 9 patients with atopic dermatitis (age: 15\u201347 years with mean \u00b1 SD 28.1 \u00b1 11.9 years; sex: 4 males, 5 females) and 20 normal control subjects (age: 16\u201345 years with mean \u00b1 SD 36.1 \u00b1 11.9 years; sex: 15 males, 5 females). &lt;b&gt;Results:&lt;\/b&gt; Serum PRL in PV (mean \u00b1 SD 25.8 \u00b1 16.1 ng\/ml) was significantly higher compared to those in atopic dermatitis (mean \u00b1 SD 9.1 \u00b1 4.7 ng\/ml) and normal control subjects (mean \u00b1 SD 10.3 \u00b1 5.3 ng\/ml; ANOVA \u2192 p = 0.0008). Three patients with PV (2 males and 1 female with ages of 35, 40 and 11 years, respectively) had the highest serum levels well above the normal range but they were &lt;100 ng\/ml, the minimum limit for the diagnosis of prolactinoma (\u03c7&lt;sup&gt;2&lt;\/sup&gt; test \u2192 p &lt;0.025). &lt;b&gt;Conclusion:&lt;\/b&gt; Since PRL belongs to the growth hormone family, its raised serum level may have a role in the hyperproliferation of kerationocytes in vivo, the hallmark of the psoriasis disease process.<\/jats:p>","DOI":"10.1159\/000017981","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:25:18Z","timestamp":1050413118000},"page":"119-122","source":"Crossref","is-referenced-by-count":38,"title":["Prolactin: Does It Have a Role in the Pathogenesis of Psoriasis?"],"prefix":"10.1159","volume":"197","author":[{"given":"A.S.M.","family":"Giasuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.I.","family":"El-Sherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.I.","family":"El-Ojali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1998,8,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/me.6.7.1023"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.105.2.197"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.114.6.874"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/17981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:54:01Z","timestamp":1745456041000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000017981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":3,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000017981","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998]]}}}