{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:26:48Z","timestamp":1790717208623,"version":"4.1.0"},"reference-count":4,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Minocycline has increasingly been associated with different adverse auto-immune reactions including drug-induced lupus. &lt;i&gt;Objective:&lt;\/i&gt; To identify the scope of minocycline-induced lupus and to characterise its typical features. &lt;i&gt;Methods:&lt;\/i&gt; Comprehensive Medline and Embase search of the English and non-English literature for case reports of minocycline-induced lupus. &lt;i&gt;Results:&lt;\/i&gt; We included 57 cases of minocycline-induced lupus (mean age \u00b1 SD at onset: 21.6 \u00b1 8.6 years, median time of exposure: 19 months, range 3 days to 6 years). All patients showed the clinical features of polyarthralgia\/polyarthritis often accompanied by liver abnormalities. Twelve patients had evidence of dermatological manifestations (i.e rash, livedo reticularis, oral ulceration, subcutaneous nodules, alopecia). The ANA test was positive in all patients. &lt;i&gt;Conclusion:&lt;\/i&gt; Long-term exposure to minocycline may be associated with drug-induced lupus. Baseline and periodic liver function and ANA tests accompanied by appropriate clinical monitoring are suggested for patients receiving long-term minocycline therapy.<\/jats:p>","DOI":"10.1159\/000018387","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:25:18Z","timestamp":1050413118000},"page":"223-231","source":"Crossref","is-referenced-by-count":97,"title":["Minocycline-Induced Lupus"],"prefix":"10.1159","volume":"200","author":[{"given":"Raymond G.","family":"Schlienger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"Bircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph R.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2000,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.133.10.1224"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.5.1471"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.5.493"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.876"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/18387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/18387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:59:04Z","timestamp":1745456344000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000018387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":4,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000018387","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000]]}}}