{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:54:22Z","timestamp":1753883662588,"version":"3.40.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Proinflammatory cytokines like TNF-\u03b1 and IL-8 have been thought to play a pivotal role in the propagation of severe acute pancreatitis (AP) and the development of its systemic complications, particularly acute lung injury. &lt;i&gt;Objective:&lt;\/i&gt; To investigate the effects of pretreatment with hydrocortisone on the production of cytokines and the occurrence of acute lung injury in rabbits with AP. &lt;i&gt;Methods:&lt;\/i&gt; AP was induced in 17 rabbits by infusion of 5% chenodeoxycholic acid into the pancreatic duct, followed by ductal ligation. The rabbits were allocated to pretreatment with subcutaneous and intravenous hydrocortisone (25\u00a0mg\/kg, respectively; n = 7) or 0.9% saline (n = 10) 30\u00a0min before induction of AP. Rabbits were observed for 12\u00a0h. Serum amylase, lipase, TNF-\u03b1, IL-8, glucose, calcium and leukocyte count were measured every 3\u00a0h. At the end of the experimental period, ascitic fluid was collected and tissue specimens from the pancreas, lungs and kidney were obtained. &lt;i&gt;Results:&lt;\/i&gt; Hydrocortisone pretreatment improved survival from 40 to 100%. Serum TNF-\u03b1 and IL-8 were lower in the hydrocortisone group than in the control group at 6\u00a0h (p = 0.006 and p &lt; 0.001, respectively). Hydrocortisone abolished leukopenia (p &lt; 0.001), hyperamylasemia (p = 0.05), the occurrence of acute lung injury and reduced the volume of ascites. &lt;i&gt;Conclusions:&lt;\/i&gt; Our findings suggest a role for TNF-\u03b1 and IL-8 in mediating the progress of AP from a local disease into a systemic illness. Hydrocortisone should be tested experimentally after the induction of AP and clinically as a prophylactic measure to avoid severe AP induced by endoscopic retrograde cholangiopancreaticography.<\/jats:p>","DOI":"10.1159\/000018730","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:25:18Z","timestamp":1050427518000},"page":"214-221","source":"Crossref","is-referenced-by-count":25,"title":["Beneficial Effects of Hydrocortisone in a Model of Experimental Acute Pancreatitis"],"prefix":"10.1159","volume":"16","author":[{"given":"Maher O.","family":"Osman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels O.","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorgen U.","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian G.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen L.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/379333a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90416-E"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(97)00240-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1998.90361"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/18730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/18730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:02:19Z","timestamp":1745470939000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000018730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":4,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1999,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000018730","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"type":"print","value":"0253-4886"},{"type":"electronic","value":"1421-9883"}],"subject":[],"published":{"date-parts":[[1999]]}}}