{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:40:03Z","timestamp":1745473203076,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Many tumor markers have been utilized in the follow-up care of colorectal cancer patients. No marker, however, has proven reliably accurate in detecting recurrent disease. &lt;i&gt;Methods:&lt;\/i&gt; The strengths and weaknesses of currently available tumor markers are reviewed, with attention to related cost and efficacy. &lt;i&gt;Results:&lt;\/i&gt; Tumor antigens, enzymes, and genetic markers have been used as tumor markers. CEA and CA 19.9 are the most widely utilized; however, genetic markers are the most promising for the future. &lt;i&gt;Conclusions:&lt;\/i&gt; Currently available markers have significant limitations. Development of genetic markers may greatly enhance our ability to predict prognosis and the need for adjuvant therapy. Marker-guided therapy may play an increasing role in this disease.<\/jats:p>","DOI":"10.1159\/000018853","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:25:18Z","timestamp":1050427518000},"page":"209-215","source":"Crossref","is-referenced-by-count":16,"title":["What\u2019s New with Tumor Markers for Colorectal Cancer?"],"prefix":"10.1159","volume":"17","author":[{"given":"Richard M.","family":"Pokorny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise E.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Galandiuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710233371702"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.270.8.943"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390403"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90260-V"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(94)00022-U"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292702"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90546-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/368258a0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90186-I"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407283310401"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502163320704"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/18853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/18853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:03:19Z","timestamp":1745470999000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000018853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000018853","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"type":"print","value":"0253-4886"},{"type":"electronic","value":"1421-9883"}],"subject":[],"published":{"date-parts":[[2000]]}}}