{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:10:09Z","timestamp":1745471409369,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Immunogenet"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>&lt;i&gt;Trichomonas vaginalis&lt;\/i&gt; is a flagellated protozoan which causes trichomoniasis, a sexually transmitted disease of the human genitourinary tract. The importance of the alternative complement pathway in host defence against &lt;i&gt;T.\u00a0vaginalis&lt;\/i&gt; was investigated in vitro. Kinetic studies utilising immunofixation following electrophoresis showed that both a strongly and weakly virulent strain of &lt;i&gt;T.\u00a0vaginalis&lt;\/i&gt; activated murine serum C3. In vivo studies with congenic-resistant, C5-deficient, B10.D2\/OSn- and C5-sufficient, B10.D2\/nSn mice showed that the presence of C5 is a significant factor in the innate host resistance to primary infection with a strongly virulent, but not a weakly virulent trichomonad strain.<\/jats:p>","DOI":"10.1159\/000019101","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"107-116","source":"Crossref","is-referenced-by-count":2,"title":["Complement-Mediated Regulation of &lt;i&gt;Trichomonas vaginalis&lt;\/i&gt; Infection in Mice"],"prefix":"10.1159","volume":"16","author":[{"given":"P.","family":"Caterina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.B.","family":"Ashman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Warton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Papadimitriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,5,19]]},"container-title":["Experimental and Clinical Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/19101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/19101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:17Z","timestamp":1745469077000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000019101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000019101","archive":["Portico"],"relation":{},"ISSN":["0254-9670","1421-9948"],"issn-type":[{"type":"print","value":"0254-9670"},{"type":"electronic","value":"1421-9948"}],"subject":[],"published":{"date-parts":[[1999]]}}}