{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:13:13Z","timestamp":1745554393680,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1998,5,22]],"date-time":"1998-05-22T00:00:00Z","timestamp":895795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,5,22]],"date-time":"1998-05-22T00:00:00Z","timestamp":895795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"The recent cloning of a G-protein-coupled, extracellular calcium [(Ca<sup>2+<\/sup>)<sub>e<\/sub>]-sensing receptor (CaR<sub>G<\/sub>) from the parathyroid, kidney and brain of several species has clarified the molecular mechanisms underlying Ca<sup>2+<\/sup>-sensing by parathyroid and other cell types. It has long been suspected that such a receptor existed on parathyroid cells, coupled to intracellular second messengers through guanine nucleotide regulatory (G) protein which is able to recognize and respond to (Ca<sup>2+<\/sup>)<sub>e<\/sub>. Recently, functional screening of a cDNA library constructed from bovine parathyroid mRNA led to the isolation of a 5.3-kb clone expressing maximal Ca<sup>2+<\/sup>-stimulated Cl<sup>\u2013<\/sup> currents in oocytes. This 5.3-kb cDNA encodes a protein of 1,085 amino acids with three principal predicted structural domains. The CaR<sub>G<\/sub> protein is present in chief parathyroid cells, in C cells of the thyroid, in the cortical thick ascending limb (TAL) and collecting duct of the kidney, and in discrete brain areas. CaR<sub>G<\/sub> may play several physiological roles. It is a central element in the control of both parathyroid and calcitonin secretion by (Ca<sup>2+<\/sup>)<sub>e<\/sub>. Moreover, functional evidence for its participation in the regulation of renal Ca<sup>2+<\/sup> reabsorption in TAL and water reabsorption in the collecting duct has been obtained. Mutations of the CaR<sub>G<\/sub> gene are responsible for hereditary and familial parathyroid disorders, and a decrease in CaR<sub>G<\/sub> expression has been documented in primary and secondary uremic hyperparathyroidism. The expression of CaR<sub>G<\/sub> in several additional organs and tissues allows speculation on the potential involvement in other pathologies.<\/jats:p>","DOI":"10.1159\/000020520","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"171-179","source":"Crossref","is-referenced-by-count":2,"title":["The Calcium Receptor in Health and Disease"],"prefix":"10.1159","volume":"6","author":[{"given":"Bernard","family":"Hory","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-C\u00e9cile","family":"Roussanne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman B.","family":"Dr\u00fceke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Bourdeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/366575a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2318"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1153"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1291"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.21.12919"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)00129-G"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)81029-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.11.5972"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2048"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199605000-00001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81002-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.11.3107"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970301)47:5<547::AID-JNR10>3.3.CO;2-T"}],"container-title":["Nephron Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/20520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/20520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:05Z","timestamp":1745469125000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000020520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5,22]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1998,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000020520","archive":["Portico"],"relation":{},"ISSN":["1660-2129"],"issn-type":[{"type":"electronic","value":"1660-2129"}],"subject":[],"published":{"date-parts":[[1998,5,22]]}}}