{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:13:14Z","timestamp":1745554394022,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[1998,9,11]],"date-time":"1998-09-11T00:00:00Z","timestamp":905472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,9,11]],"date-time":"1998-09-11T00:00:00Z","timestamp":905472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<jats:p>Major advances in nuclear magnetic resonance (NMR) spectroscopic methods and technology have led to the increased use of this technique to study kidney metabolism and function. These studies include: (1) the identification of organic osmolytes in the renal medulla and their role as potential markers of medullary development and damage; (2) changes in renal epithelial cell organic solute transport, such as autosomal dominant polycystic kidney disease, and (3) the biochemical heterogeneity of the nephron and identification of markers of site-specific renal damage in experimental animals and man. The present review summarises these data with the aim of demonstrating how NMR can be used as an indirect, and non-invasive probe of homeostatic mechanisms in vivo and in vitro.<\/jats:p>","DOI":"10.1159\/000020549","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"409-414","source":"Crossref","is-referenced-by-count":9,"title":["Nuclear Magnetic Resonance Spectroscopy: A Non-Invasive Probe of Kidney Metabolism and Function"],"prefix":"10.1159","volume":"6","author":[{"given":"Peta J.D.","family":"Foxall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy K.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(92)90074-S"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.8.4717"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19971201)279:5<436::AID-JEZ5>3.0.CO;2-P"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050031"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00747.x"}],"container-title":["Nephron Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/20549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/20549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:17Z","timestamp":1745469137000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000020549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,11]]},"references-count":5,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1998,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000020549","archive":["Portico"],"relation":{},"ISSN":["1660-2129"],"issn-type":[{"type":"electronic","value":"1660-2129"}],"subject":[],"published":{"date-parts":[[1998,9,11]]}}}