{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:30:38Z","timestamp":1782275438236,"version":"3.54.5"},"reference-count":4,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>&lt;i&gt;Background and Objective: &lt;\/i&gt;Recently, attention has been focused on endothelin-1 (ET-1) as an indicator of atherosclerosis. However, normal levels of ET-1 are frequently found in elderly patients. We investigated the relationships between echocardiographic findings and ET-1 in 117 inpatients for rehabilitation. &lt;i&gt;Methods: &lt;\/i&gt;The patients were 34 men and 83 women, 83.4 \u00b1 0.8 years old (mean \u00b1 SE), with the following diseases: cerebrovascular diseases (n = 83), cardiovascular diseases of New York Heart Association Class I or II (n = 57), diabetes mellitus (n = 11) and hyperlipidemia (n = 12). Ejection fraction (EF) and left ventricular mass index (LVMI) were calculated by echocardiographic studies. &lt;i&gt;Results: &lt;\/i&gt;The average ET-1 was within the normal range, but a significant positive correlation was observed between age and ET-1 (ET-1 = 1.8 \u00b1 0.1\u00a0pg\/ml, r = 0.248, p &lt; 0.01). Moreover, plasma ET-1 was positively correlated to total cholesterol and to low density lipoprotein cholesterol in patients with a history of hypertension (n = 41, r = 0.318 and r = 0.314, both p &lt; 0.05). Gender was not a significant factor. There was no significant difference in ET-1 between patients with mild renal dysfunction (n = 54) and patients with normal renal function (n = 63) (blood urea nitrogen = 30.9 \u00b1 2.4 vs. 15.1 \u00b1 0.5\u00a0mg\/dl, serum creatinine = 1.03 \u00b1 0.06 vs. 0.59 \u00b10.02\u00a0mg\/dl, ET-1 = 1.7 \u00b1 0.1 vs. 1.8 \u00b1 0.1\u00a0pg\/ml), or between patients with (n = 50) and without (n = 67) left ventricular hypertrophy (LVMI = 146 \u00b1 6 vs. 83 \u00b1 2\u00a0g\/m&lt;sup&gt;2&lt;\/sup&gt;, ET-1 = 1.8 \u00b1 0.1 vs. 1.8 \u00b1 0.1\u00a0pg\/ml). There was no difference in ET-1 between patients with EF &lt;50% (n = 27) and EF \u226550% (n = 90) (ET-1 = 1.8 \u00b1 0.2 vs. 1.7 \u00b1 0.1\u00a0pg\/ml). &lt;i&gt;Conclusion: &lt;\/i&gt;There were no significant relationships between echocardiographic findings and ET-1 in elderly subjects without overt heart failure. However, in patients with a history of hypertension, measuring ET-1 may be useful for estimating the extent of atherosclerosis.<\/jats:p>","DOI":"10.1159\/000022111","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"312-316","source":"Crossref","is-referenced-by-count":11,"title":["Does the Plasma Endothelin-1 Concentration Reflect Atherosclerosis in the Elderly?"],"prefix":"10.1159","volume":"45","author":[{"given":"Harumi","family":"Sayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Konoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1999,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/348730a0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/348732a0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80489-7"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/22111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/22111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:41:22Z","timestamp":1745469682000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000022111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":4,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000022111","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"value":"0304-324X","type":"print"},{"value":"1423-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999]]}}}