{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:10:20Z","timestamp":1745471420064,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>Zahlreiche Behandlungsm\u00f6glichkeiten der Symptome des Lichen sclerosus, mit meist geringem Erfolg, wurden bisher beschrieben. Testosteron 2% lokal galt w\u00e4hrend Jahren als Therapie der Wahl, wobei Erfolgsraten zwischen 67 und 100% berichtet wurden. Neuere mit Plazebo kontrollierte Untersuchungen zeigten Remissionsraten von lediglich 20% (Testosteron) and 10% (Plazebo). Bei lokaler Applikation von Kortikosteroiden der Klasse 4 (z.B. Clobetasol 0,05%) hingegen wurden Remissionsraten bis zu 75% beobachtet, wobei die bef\u00fcrchteten kortikosteroidbedingten Nebenwirkungen, wie z.B. Hautatrophie, auch bei mehrw\u00f6chiger Applikation kein Problem darstellten.<\/jats:p>","DOI":"10.1159\/000022325","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"29-32","source":"Crossref","is-referenced-by-count":3,"title":["Lichen sclerosus \u2013 hormonelle Therapie heute"],"prefix":"10.1159","volume":"40","author":[{"given":"Fides","family":"K\u00fcng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199502000-00028"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199603000-00023"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/22325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/22325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:42:25Z","timestamp":1745469745000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000022325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":2,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000022325","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"type":"print","value":"1018-8843"},{"type":"electronic","value":"1423-0011"}],"subject":[],"published":{"date-parts":[[2000]]}}}