{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:49:29Z","timestamp":1763765369599,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2000,10,30]],"date-time":"2000-10-30T00:00:00Z","timestamp":972864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,10,30]],"date-time":"2000-10-30T00:00:00Z","timestamp":972864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Hered"],"published-print":{"date-parts":[[2001]]},"abstract":"Low-grade B cell lymphomas of mucosa-associated lymphoid tissue (MALT) represent a distinct clinicopathological entity that arises in a wide variety of extranodal sites. Genetically, MALT lymphomas are characterized by the t(11;18)(q21;q21). The genes involved in this translocation have been identified to be <i>API2<\/i> on chromosome 11, which encodes an apoptotic inhibitor, and <i>MALT1<\/i>, a novel gene on chromosome 18. We identified the t(11;18)(q21;q21) by Southern blot analysis and reverse transcriptase PCR in 42% of a panel of extranodal MALT lymphomas. We also identified the breakpoints within the <i>API2<\/i> and <i>MALT1<\/i> genes in 7 patients, which revealed a consistent breakpoint after the third baculoviral inhibitor of apoptosis repeat domain within <i>API2<\/i>, and variable breakpoints in <i>MALT1<\/i>. We determined the <i>API2\/MALT1<\/i> fusion transcript in 2 cases by Northern blot analysis and also showed that <i>MALT1<\/i> mRNA is constitutively expressed in a variety of human tissues. To understand the functional consequence of the translocation, we determined the pattern of expression of <i>API2<\/i> and <i>MALT1<\/i> through B lineage differentiation. <i>API2<\/i> was expressed only in cell lines which correspond to mature B cells, whereas <i>MALT1<\/i> mRNA was detectable in pre-B cells, mature B cells and plasma cells. These results suggest that fusion of <i>MALT1<\/i> to <i>API2<\/i> mediated by the t(11;18)(q21;q21) may result in an increased inhibition of germinal center B cell apoptosis and subsequent development of MALT lymphomas.<\/jats:p>","DOI":"10.1159\/000022952","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["The <i>API2\/MALT1<\/i> Fusion Product May Lead to Germinal Center B Cell Lymphomas by Suppression of Apoptosis"],"prefix":"10.1159","volume":"51","author":[{"given":"Archontoula","family":"Stoffel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Le Beau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199902)24:2<156::AID-GCC9>3.0.CO;2-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199904)24:4<315::AID-GCC4>3.3.CO;2-W"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90149-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/379349a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.4974"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900940"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.19.10057"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.23.6914"}],"container-title":["Human Heredity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/22952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/22952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:48:26Z","timestamp":1745470106000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000022952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10,30]]},"references-count":8,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2000,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000022952","archive":["Portico"],"relation":{},"ISSN":["0001-5652","1423-0062"],"issn-type":[{"type":"print","value":"0001-5652"},{"type":"electronic","value":"1423-0062"}],"subject":[],"published":{"date-parts":[[2000,10,30]]}}}