{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:48:46Z","timestamp":1761742126083,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>To investigate the relationship between leptin levels and IDDM with and without microalbuminuria, fasting serum levels of leptin, insulin, insulin-like growth factor-1 (IGF-1), sex hormone-binding globulin (SHBG), testosterone (SHBG) ratio, blood pressure and body mass index (BMI) were measured in 18 normo- and 11 microalbuminuric females with &gt;5 years of IDDM, and 24 healthy controls in late puberty. Leptin levels were higher in micro- than normoalbuminuric IDDM patients, and lower in healthy controls than in both IDDM groups (p &lt; 0.05, respectively). In multiple regression analysis, presence of IDDM and BMI independently contributed to increased leptin values (R&lt;sup&gt;2&lt;\/sup&gt; = 0.34, p &lt; 0.001). Including IDDM females only, solely low IGF-1 and high testosterone\/SHBG were associated with leptin (R&lt;sup&gt;2&lt;\/sup&gt; = 0.39, p = 0.009). Albumin excretion rate (AER) was correlated to leptin (r = 0.48, p = 0.01). With AER as the dependent variable only serum leptin and diastolic blood pressure added to the regression (R&lt;sup&gt;2&lt;\/sup&gt; = 0.59, p &lt; 0.001). In conclusion, serum leptin, independently of BMI, is: (1) increased in IDDM females of late puberty; (2) associated with low IGF-1 and hyperandrogenemia, and (3) related to increased albumin excretion rate in IDDM females.<\/jats:p>","DOI":"10.1159\/000023294","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"297-302","source":"Crossref","is-referenced-by-count":22,"title":["Serum Leptin Levels in Young Females with Insulin-Dependent Diabetes and the Relationship to Hyperandrogenicity and Microalbuminuria"],"prefix":"10.1159","volume":"50","author":[{"given":"S.","family":"Rudberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Persson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1195-1155"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.6.1697"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.6.1692"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.6.1687"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91943-G"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/080370500448687"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/23294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/23294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:49:41Z","timestamp":1745470181000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000023294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":6,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1998,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000023294","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[1998]]}}}