{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:14:06Z","timestamp":1745554446599,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>These experiments explored the mechanism underlying FSH hypersecretion on estrous afternoon in rats injected with RU486 (RU) on proestrus. Four-day cyclic rats were injected with RU at 12:00\u00a0h on proestrus (1 or 4\u00a0mg\/0.2\u00a0ml oil; s.c.), and its effects on LH and FSH secretion at 18:30\u00a0h on estrus were compared with those of antiprogestagens ZK299 (ZK) (1 or 4\u00a0mg\/0.2\u00a0ml oil; s.c.) and Org31806 (OR) (2 or 8\u00a0mg\/0.2\u00a0ml oil; s.c.). Additionally, rats treated with RU or nembutal (PB) (60\u00a0mg\/kg; i.p. at 13:00\u00a0h on proestrus) were injected with an LHRH antagonist (LHRHa) at 10:00\u00a0h on estrus (1\u00a0mg\/0.2\u00a0ml saline; s.c.) or progesterone (P) (7.7, 15.5 or 30.9\u00a0mg\/0.2\u00a0ml oil; s.c.) on proestrus at 10:00\u00a0h in RU-injected rats and at 14:00\u00a0h in PB-injected rats. Animals were killed by decapitation at 18:30\u00a0h on estrus and serum LH and FSH concentrations were determined. Rats trated with 1 or 4\u00a0mg of RU or Org or 4\u00a0mg of ZK recorded increased serum FSH on estrous afternoon, while 1\u00a0mg ZK had no effect. PB increased mainly serum LH levels and, to a lesser extent, FSH levels. P decreased serum FSH concentrations in both RU- and PB-injected rats. LHRHa reversed the effects of PB on FSH secretions, but reduced FSH hypersecretion induced by RU only. These results are interpreted to mean that, in the absence of proestrous afternoon P-inhibitory action of the neural stimulus controlling LHRH release, FSH secretion on estrous afternoon involves two components: one is LHRH dependent while, in contrast to LH secretion, the other is LHRH independent, and only expressed in a low estrogen background.<\/jats:p>","DOI":"10.1159\/000023311","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T17:26:45Z","timestamp":1050427605000},"page":"37-42","source":"Crossref","is-referenced-by-count":1,"title":["Mechanism of the Stimulatory Action of Antisteroid RU486 on Follicle-Stimulating Hormone Secretion in the Cyclic Rat"],"prefix":"10.1159","volume":"51","author":[{"given":"J.E.","family":"S\u00e1nchez-Criado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"T\u00e9bar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/er.13.2.146"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(83)90030-8"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/23311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/23311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:49:55Z","timestamp":1745470195000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000023311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":2,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000023311","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[1999]]}}}