{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:14:12Z","timestamp":1793279652188,"version":"4.5.0"},"reference-count":8,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>Human resistance to reinfection with Schistosoma mansoni and Schistosoma haematobium correlates with elevated IgE titers against worm antigens (soluble worm antigen preparation, SWAP). In S. mansoni infection, low levels of reinfection following chemotherapy are associated with the recognition of a cloned tegumental protein Sm22.6. Because of potential species\u2013specific differences in resistance to schistosomes, we attempted to identify Schistosoma japonicum antigens recognized by human IgE. Following a survey of 176 infected individuals in Leyte, Philippines, we show that IgE antibodies from the majority of older, high\u2013IgE\/SWAP responders recognize antigens in the 22 (Sj22)\u2013, 45\u2013, 78\u2013 and 97\u2013kDa range in SWAP. Limited IgE cross\u2013reactivity between Sj22 and Sm22 was observed following a comparison of Filipino IgE responses to these antigens. The antigen was cloned from an adult S. japonicum \u03bb\u2013ZAP cDNA library (Mindoro strain) by immunoscreening with pooled high\u2013titer IgE antisera and a rabbit anti\u2013Sj22 polyclonal antibody. The deduced amino acid sequence of the identified cDNA clone, MJ\u20131, showed significant homology to Sm22.6 (74%) and Sj22.6 (99%). Although the molecular sequence of Sj22.6 has already been reported, this is the first demonstration of its recognition by human IgE, thereby strengthening its potential as a vaccine candidate. Using an overlapping peptide approach, four IgE\u2013binding epitopes were identified in Sj22.6, two of which exhibited similarities to known IgE\u2013binding epitopes from codfish (Gad c 1) and \u03b2\u2013lactoglobulin\u2013related allergens. These findings suggest that allergy and protective immunity to helminth infection may be linked by the structural similarities of epitopes recognized by human IgE.<\/jats:p>","DOI":"10.1159\/000023995","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"94-104","source":"Crossref","is-referenced-by-count":63,"title":["Identification of the Schistosoma japonicum 22.6\u2013kDa Antigen as a Major Target of the Human IgE Response: Similarity of IgE\u2013Binding Epitopes to Allergen Peptides"],"prefix":"10.1159","volume":"117","author":[{"given":"Mario Luis","family":"Santiago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius Clemence R.","family":"Hafalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Kurtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemiliano L.","family":"Aligui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Wiest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remigio M.","family":"Olveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Richard","family":"Olds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette L.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1998,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/349243a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)90271-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S003118209600858X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1976.9999"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(86)90106-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(92)90218-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.23.14509"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.52.31196"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/23995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/23995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:53:32Z","timestamp":1745470412000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000023995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000023995","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998]]}}}