{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:14:18Z","timestamp":1745554458105,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>&lt;b&gt;Background:&lt;\/b&gt; There are substantial differences in immune\u2013mediated disease prevalence between different countries and populations which cannot be explained by genetic variability. &lt;b&gt;Aims:&lt;\/b&gt; To compare the prevalence of antinuclear (ANA), antimitochondrial, antireticulin, liver\u2013kidney microsomal, parietal cell, thyroid microsomal and double\u2013stranded DNA (dsDNA) antibodies among adults aged 20\u201344 years in two towns, i.e. in Tartu, Estonia (n = 448) and in Uppsala, Sweden (n = 532) with a low and a high prevalence of allergy. &lt;b&gt;Methods:&lt;\/b&gt; For autoantibody detection, standard indirect immunofluorescence tests on tissue and Chritidia lucilia antigenic preparations were used (sera were diluted starting from 1:10). &lt;b&gt;Results:&lt;\/b&gt; The prevalence of ANA was lower in Tartu than in Uppsala (3 vs. 10% among males and 11 vs. 16% among females; p&lt;0.01 and p&lt;0.1, respectively). Furthermore, dsDNA antibody\u2013positive cases were only identified in Uppsala. The largest difference between the two populations was revealed for IgM type ANA, both among males (1 vs. 6%; p&lt;0.02) and females (5 vs. 11%; p&lt;0.01). In addition, the antibody titers were lower in Tartu than in Uppsala (p&lt;0.05). The prevalence of other autoantibodies was similar in the two towns. &lt;b&gt;Conclusions:&lt;\/b&gt; The findings could support that Th2\u2013like immune responses are commoner in Sweden than in Estonia, as previously suggested by the higher prevalence of allergy.<\/jats:p>","DOI":"10.1159\/000023999","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"126-130","source":"Crossref","is-referenced-by-count":8,"title":["Autoantibodies in Estonia and  Sweden, Populations with Different Responses to Allergens"],"prefix":"10.1159","volume":"117","author":[{"given":"Raivo","family":"Uibo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ija","family":"Talja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rain","family":"J\u00f4gi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Janson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eythor","family":"Bj\u00f6rnsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Boman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maire","family":"Mandel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Bj\u00f6rkst\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1994.1122"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.3.839"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199805)41:5<838::AID-ART10>3.3.CO;2-J"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/23999","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/23999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:53:36Z","timestamp":1745470416000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000023999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":3,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000023999","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[1998]]}}}