{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:14:18Z","timestamp":1745554458071,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>Treatment with recombinant interleukin\u20133 (rIL\u20133) augmented IL\u20134 production of spleen cells in mice infected with Trichinella spiralis. In a previous report, we showed that treatment with rIL\u20133 accelerated IgE responsiveness in mice. We have examined IL\u20134 and interferon (IFN)\u2013\u03b3 production by spleen cells from both rIL\u20133\u2013treated and untreated mice during the early stages of infection. The results indicated that IL\u20134 production was enhanced in rIL\u20133\u2013treated mice compared to that in untreated mice. In contrast, there was no difference in IFN\u2013\u03b3 production between the two groups. Augmentation of IL\u20134 production was dependent on the dose of rIL\u20133 injected before infection. To examine if the treatment with rIL\u20133 affects T cell function, spleen cells from mice treated with various doses of rIL\u20133 were cultured under the stimulation with anti\u2013CD3 (T cell receptor complex) mAb and then assessed for cytokine production. IL\u20134 production increased depending on the dose of rIL\u20133, while IFN\u2013\u03b3 production did not. Furthermore, spleen cells were separated by surface markers, Thy1.2, CD4 and CD8. Thy1.2+ cell population responded significantly to produce IL\u20134 after anti\u2013CD3 stimulation, when compared with IL\u20134 production of Thy1.2\u2013 cell population. A major producer of IL\u20134 in T cells was CD4+ cell population but not CD8+ cell population. IL\u20134 production was suppressed in rIL\u20133\u2013treated mice injected with anti\u2013CD4 mAb. These results suggest that IL\u20133 might play a role as Th2 amplifier in immune response to parasite infection.<\/jats:p>","DOI":"10.1159\/000024000","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"131-137","source":"Crossref","is-referenced-by-count":3,"title":["Exogenous Interleukin\u20133 Enhances IL\u20134 Production by Splenic CD4+ Cells during the Early Stages of a Trichinella spiralis Infection"],"prefix":"10.1159","volume":"117","author":[{"given":"Masataka","family":"Korenaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Akimaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Hashiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1998,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)80606-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/32190"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/366245a0"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/24000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/24000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:53:36Z","timestamp":1745470416000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000024000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":3,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000024000","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[1998]]}}}