{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:42:02Z","timestamp":1759963322537,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>&lt;b&gt;Background: &lt;\/b&gt;Antigen\u2013induced upregulation of cytokines, especially Th2\u2013type cytokines, has been proven to be closely related to allergic inflammation in nasal allergy. CD4\u2013positive T cells are supposed to play an important role not only in the induction of allergy but also in allergic inflammation. &lt;b&gt;Methods: &lt;\/b&gt;The anti\u2013CD4 mAb was administered to the murine model of nasal allergy either at the beginning of sensitization, just before antigen challenge or during a topical booster sensitization. Then, the effects on the antigen\u2013induced nasal responses and the serum level of antigen\u2013specific IgE antibody were evaluated. &lt;b&gt;Results: &lt;\/b&gt;When the mAb was applied at the beginning of sensitization, the early\u2013phase nasal symptoms and the late\u2013phase nasal eosinophilia were significantly inhibited, and the 8\u2013day passive cutaneous anaphylaxis (PCA) titer tended to be inhibited. When the mAb was applied just before the challenge, there were no differences in the nasal symptoms, the nasal eosinophilia or the 8\u2013day PCA titer between the mAb\u2013treated animals and the control animals. When the mAb was applied during a topical booster sensitization, the nasal eosinophilia, the 8\u2013day PCA titer and histamine hypersensitivity were significantly suppressed in the treated animals. &lt;b&gt;Conclusion: &lt;\/b&gt;CD4\u2013positive T cells play an important role in the induction of IgE\u2013mediated nasal allergy, occurrence of late\u2013phase allergic inflammation and histamine hypersensitivity, but not in antigen\u2013induced early\u2013phase nasal symptoms in the murine model. In cases of chronic topical antigen exposure, however, the suppressive effects of a single application of the anti\u2013CD4 mAb are not remarkable.<\/jats:p>","DOI":"10.1159\/000024029","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"37-43","source":"Crossref","is-referenced-by-count":11,"title":["Role of CD4\u2013Positive T Cells in the Pathogenesis of Nasal Allergy in the Murine Model"],"prefix":"10.1159","volume":"118","author":[{"given":"Hideki","family":"Ogasawara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akikatsu","family":"Kataura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1994.1203"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/24029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/24029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:54:07Z","timestamp":1745470447000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000024029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":1,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000024029","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[1999]]}}}