{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:56Z","timestamp":1787017856188,"version":"build-2736575974"},"reference-count":2,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>&lt;b&gt;Background: &lt;\/b&gt;Chronic urticaria is a common disease, though only few data on its natural course are available. In most cases the cause cannot be determined. Recently a relationship of chronic urticaria to infection with &lt;i&gt;Helicobacter pylori&lt;\/i&gt; (HP) has been postulated, but no controlled study has been performed to prove this association. &lt;b&gt;Methods: &lt;\/b&gt;In this prospective study the clinical course and rate of HP infection in 46 patients with chronic \u2018idiopathic\u2019 urticaria were investigated. Infected patients were treated in a double\u2013blind placebo\u2013controlled crossover study with amoxycillin and lansoprazol. Eradication and clinical course were followed up 2 months after each treatment, respectively, 3 and 6 months after the first consultation. &lt;b&gt;Results: &lt;\/b&gt;In 19\/46 (41%) the chronic \u2018idiopathic\u2019 urticaria resolved within 6 months. 12 patients (24%) were infected with HP, which corresponds to the infection rate of the population at comparable ages without urticaria in Switzerland. Eradication of HP was achieved in 3, but only in 1 was the eradication associated with the resolution of urticaria. &lt;b&gt;Conclusions: &lt;\/b&gt;Our data show that in young patients with a rather short history of chronic urticaria frequently a rather favourable natural course of chronic idiopathic urticaria can be seen. No association between HP infection and chronic urticaria could be demonstrated.<\/jats:p>","DOI":"10.1159\/000024176","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T06:10:37Z","timestamp":1050387037000},"page":"60-63","source":"Crossref","is-referenced-by-count":73,"title":["Chronic Idiopathic Urticaria:  Natural Course and Association with Helicobacter pylori Infection"],"prefix":"10.1159","volume":"119","author":[{"given":"Benno","family":"Schnyder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Helbling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner J.","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1999,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506293322608"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000023958"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/24176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/24176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:55:43Z","timestamp":1745456143000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000024176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":2,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1999,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000024176","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999]]}}}