{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:11:05Z","timestamp":1745554265857,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[1998]]},"abstract":"<jats:p>Vasodilation originating within a muscle is conducted into feed arteries, but the determinants of conduction along feed arteries are undefined. We have investigated the effect of vasomotor tone on conducted vasodilation in feed arteries of the hamster retractor muscle. Unbranched segments (length, 2\u20133\u00a0mm) were isolated, cannulated, and studied in vitro at 37\u00b0C while pressurized to 25\u00a0mm Hg, 75\u00a0mm Hg (in vivo pressure), or 120\u00a0mm Hg in the absence and presence of norepinephrine (NE, 10&lt;sup&gt;\u20137&lt;\/sup&gt; &lt;i&gt;M&lt;\/i&gt; + 10&lt;sup&gt;\u20136&lt;\/sup&gt;\u00a0&lt;i&gt;M&lt;\/i&gt; propanolol). Internal diameter decreased (p &lt; 0.05) as pressure increased (85 \u00b1 7, 73 \u00b1 4, 66 \u00b1 6\u00a0\u00b5m, respectively), confirming myogenic reactivity. Acetylcholine (ACh, 0.1\u00a0&lt;i&gt;M&lt;\/i&gt;) was delivered (1\u00a0\u00b5A, 500\u00a0ms) from a micropipette; vasomotor responses were recorded at the site of release (\u2018local\u2019) and at distances up to 1,500\u00a0\u00b5m (\u2018conducted\u2019) along the vessel. There were no responses to ACh at 25\u00a0mm Hg. However, dilations (diameter change, \u00b5m) were pronounced at 75\u00a0mm Hg (local: 22 \u00b1 3; conducted: 18 \u00b1 2, respectively), without further change at 120\u00a0mm Hg. NE constricted vessels (p &lt; 0.05) at each pressure (to 65 \u00b1 9, 57 \u00b1 6, and 56 \u00b1 8\u00a0\u00b5m, respectively); this enabled both local (14 \u00b1 2\u00a0\u00b5m) and conducted (10 \u00b1 1\u00a0\u00b5m) vasodilation at 25\u00a0mm Hg but was without effect on conduction at 75 or 120\u00a0mm Hg. Our findings indicate that conducted responses plateau at a physiological level of myogenic tone. Whereas NE had no effect on conduction under normal or hypertensive conditions, it enabled conduction during hypotension. We conclude that pressure and NE influence the ability of conducted vasodilation to govern muscle blood flow.<\/jats:p>","DOI":"10.1159\/000025611","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T09:24:25Z","timestamp":1050398665000},"page":"405-412","source":"Crossref","is-referenced-by-count":6,"title":["Role of Smooth Muscle Activation in Conduction of Vasodilation along Isolated Hamster Feed Arteries"],"prefix":"10.1159","volume":"35","author":[{"given":"Bryan D.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Segal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/336382a0"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/25611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/25611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:52Z","timestamp":1745466592000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000025611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":1,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1998,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000025611","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"type":"print","value":"1018-1172"},{"type":"electronic","value":"1423-0135"}],"subject":[],"published":{"date-parts":[[1998]]}}}