{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:04:04Z","timestamp":1758819844893,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1999,10,15]],"date-time":"1999-10-15T00:00:00Z","timestamp":939945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,10,15]],"date-time":"1999-10-15T00:00:00Z","timestamp":939945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>We examined the effects of angiotensin\u2013converting enzyme inhibitor (ACEI) and angiotensin II type 1 receptor antagonist (AT1a) on the action of protooncogene c\u2013fos in salt\u2013sensitive hypertensive rats. Seven\u2013week old Dahl salt\u2013sensitive rats fed a high (8%)\u2013salt diet were treated with ACEI, cilazapril (10 mg\/kg) or AT1a, TCV\u2013116 (1mg\/ kg) every day for 6 weeks. The control animals were fed a low (0.3%)\u2013salt diet. Systolic blood pressure gradually increased in high\u2013salt\u2013loaded rats and was higher than low\u2013salt\u2013treated rats throughout the study. However, both medications had no significant antihypertensive effect. After 6 weeks of therapy, glomerular mRNA and nuclear protein were extracted from the resected kidneys. Competitive reverse transcription\u2013polymerase chain reaction showed a high level of glomerular c\u2013fos mRNA in high\u2013salt\u2013loaded rats and that ACEI or AT1a treatment did not significantly change its level. Electrophoretic mobility shift assay demonstrated that treatment with AT1a significantly decreased the activator protein\u20131 (AP\u20131) binding activity in the glomerular nuclear extract compared to ACEI. Our findings suggest that, compared with ACEI treatment, long\u2013term treatment with AT1a may contribute to attenuation of the glomerular injury in salt\u2013sensitive hypertension by inhibiting AP\u20131 transcription activity independent of its antihypertensive effect.<\/jats:p>","DOI":"10.1159\/000025952","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T09:24:25Z","timestamp":1050398665000},"page":"35-41","source":"Crossref","is-referenced-by-count":6,"title":["Chronic Treatment with Angiotensin II Type 1 Receptor Antagonist Suppresses Glomerular Activator Protein\u20131 Activity in Salt\u2013Sensitive Hypertensive Rats"],"prefix":"10.1159","volume":"23","author":[{"given":"Fumio","family":"Otsuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingo","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,10,15]]},"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/25952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/25952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:52:48Z","timestamp":1745466768000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000025952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10,15]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000025952","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[1999,10,15]]}}}